Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/fear-conditioning-drives-profilin-into-amygdala-dendritic-spines-591aSCxd17
References (14)
-
Y. Fukazawa, Y. Saitoh, F. Ozawa, Y. Ohta, K. Mizuno, K. Inokuchi (2003)
Hippocampal LTP Is Accompanied by Enhanced F-Actin Content within the Dendritic Spine that Is Essential for Late LTP Maintenance In VivoNeuron, 38
-
Y. Takumi, V. Ramírez-León, P. Laake, E. Rinvik, O. Ottersen (1999)
Different modes of expression of AMPA and NMDA receptors in hippocampal synapsesNature Neuroscience, 2
-
R. Lamprecht, Joseph LeDoux (2004)
Structural plasticity and memoryNature Reviews Neuroscience, 5
-
(2003)
NATURE NEUROSCIENCE VOLUME -
S. Rumpel, Joseph LeDoux, A. Zador, R. Malinow (2005)
Postsynaptic Receptor Trafficking Underlying a Form of Associative LearningScience, 308
-
Y. Geinisman, R. Berry, J. Disterhoft, J. Power, E. Zee (2001)
Associative Learning Elicits the Formation of Multiple-Synapse BoutonsThe Journal of Neuroscience, 21
-
C. Bailey, E. Kandel, Kausik Si (2004)
The Persistence of Long-Term Memory A Molecular Approach to Self-Sustaining Changes in Learning-Induced Synaptic GrowthNeuron, 44
-
O. Millhouse, J. DeOlmos (1983)
Neuronal configurations in lateral and basolateral amygdalaNeuroscience, 10
-
H. Neuhoff, M. Sassoè-Pognetto, P. Panzanelli, Christoph Maas, W. Witke, M. Kneussel (2005)
The actin‐binding protein profilin I is localized at synaptic sites in an activity‐regulated mannerEuropean Journal of Neuroscience, 21
-
B. Leuner, Jacqueline Falduto, T. Shors (2003)
Associative Memory Formation Increases the Observation of Dendritic Spines in the HippocampusThe Journal of Neuroscience, 23
-
Joseph LeDoux (2000)
Emotion Circuits in the BrainAnnual Review of Neuroscience, 23
-
M. Ackermann, A. Matus (2003)
Activity-induced targeting of profilin and stabilization of dendritic spine morphologyNature Neuroscience, 6
-
W. Witke (2004)
The role of profilin complexes in cell motility and other cellular processes.Trends in cell biology, 14 8
-
S. Rodrigues, C. Farb, E. Bauer, Joseph LeDoux, G. Schafe (2004)
Pavlovian Fear Conditioning Regulates Thr286 Autophosphorylation of Ca2+/Calmodulin-Dependent Protein Kinase II at Lateral Amygdala SynapsesThe Journal of Neuroscience, 24
- Publisher
- Springer Journals
- Copyright
- Copyright © 2006 by Nature Publishing Group
- Subject
- Biomedicine; Biomedicine, general; Neurosciences; Behavioral Sciences; Biological Techniques; Neurobiology; Animal Genetics and Genomics
- ISSN
- 1097-6256
- eISSN
- 1546-1726
- DOI
- 10.1038/nn1672
- Publisher site
- See Article on Publisher Site
Abstract
Changes in spine morphology may underlie memory formation, but the molecular mechanisms that subserve such alterations are poorly understood. Here we show that fear conditioning in rats leads to the movement of profilin, an actin polymerization–regulatory protein, into dendritic spines in the lateral amygdala and that these spines undergo enlargements in their postsynaptic densities (PSDs). A greater proportion of profilin-containing spines with enlarged PSDs could contribute to the enhancement of associatively induced synaptic responses in the lateral amygdala following fear learning.
Journal
Nature Neuroscience – Springer Journals
Published: Mar 19, 2006