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Baseline and Early Natural History Report: The Central Vein Occlusion Study

Baseline and Early Natural History Report: The Central Vein Occlusion Study Abstract Objectives: To evaluate panretinal photocoagulation for ischemic central vein occlusion and macular grid-pattern photocoagulation for macular edema with reduced visual acuity due to central vein occlusion and to further define the natural history of central vein occlusion. Design: A multicenter randomized controlled clinical trial supported by the National Eye Institute, Bethesda, Md. Patients: A total of 728 eyes from 725 patients were entered into one or more of four study groups: perfused, nonperfused, indeterminate perfusion, and macular edema. Results: Follow-up of study patients is still in progress and no results are available for the randomized groups (nonperfused and macular edema). Thirtyeight (83%) of 46 evaluable eyes in the indeterminate group eventually demonstrated at least 10 disc areas of nonperfusion (28 eyes) or developed iris and/or angle neovascularization before retinal status could be determined (10 eyes). Four-month follow-up information is available for 522 of the 547 eyes in the perfused group. Thirty of these 522 eyes demonstrated iris and/or angle neovascularization at or before the 4-month follow-up visit. An additional 51 eyes had developed evidence of at least 10 disc areas of nonperfusion by the time of the 4-month visit. Conclusions: These findings confirm the importance of frequent follow-up examinations, including undilated slitlamp examination of the iris, and gonioscopy in the management of all patients with recent onset of central vein occlusion. References 1. SAS Institute Inc. SAS/STAT(r) User's Guide, Version 6 . 4th ed. Cary, NC: SAS Institute Inc; 1989;2:1071-1134. 2. Zegarra H, Gutman FA, Conforto J. The natural course of central retinal vein occlusion . Ophthalmology . 1979;86:1931-1939.Crossref 3. Hayreh SS, Rojas P, Podhajsky P, Montague P, Woolson RF. Ocular neovascularization with retinal vascular occlusion, III: incidence of ocular neovascularization with retinal vein occlusion . Ophthalmology . 1983;90:488-506.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Baseline and Early Natural History Report: The Central Vein Occlusion Study

Archives of Ophthalmology , Volume 111 (8) – Aug 1, 1993
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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1993 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1993.01090080083022
Publisher site
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Abstract

Abstract Objectives: To evaluate panretinal photocoagulation for ischemic central vein occlusion and macular grid-pattern photocoagulation for macular edema with reduced visual acuity due to central vein occlusion and to further define the natural history of central vein occlusion. Design: A multicenter randomized controlled clinical trial supported by the National Eye Institute, Bethesda, Md. Patients: A total of 728 eyes from 725 patients were entered into one or more of four study groups: perfused, nonperfused, indeterminate perfusion, and macular edema. Results: Follow-up of study patients is still in progress and no results are available for the randomized groups (nonperfused and macular edema). Thirtyeight (83%) of 46 evaluable eyes in the indeterminate group eventually demonstrated at least 10 disc areas of nonperfusion (28 eyes) or developed iris and/or angle neovascularization before retinal status could be determined (10 eyes). Four-month follow-up information is available for 522 of the 547 eyes in the perfused group. Thirty of these 522 eyes demonstrated iris and/or angle neovascularization at or before the 4-month follow-up visit. An additional 51 eyes had developed evidence of at least 10 disc areas of nonperfusion by the time of the 4-month visit. Conclusions: These findings confirm the importance of frequent follow-up examinations, including undilated slitlamp examination of the iris, and gonioscopy in the management of all patients with recent onset of central vein occlusion. References 1. SAS Institute Inc. SAS/STAT(r) User's Guide, Version 6 . 4th ed. Cary, NC: SAS Institute Inc; 1989;2:1071-1134. 2. Zegarra H, Gutman FA, Conforto J. The natural course of central retinal vein occlusion . Ophthalmology . 1979;86:1931-1939.Crossref 3. Hayreh SS, Rojas P, Podhajsky P, Montague P, Woolson RF. Ocular neovascularization with retinal vascular occlusion, III: incidence of ocular neovascularization with retinal vein occlusion . Ophthalmology . 1983;90:488-506.Crossref

Journal

Archives of Ophthalmology – American Medical Association

Published: Aug 1, 1993

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