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MEMORY DISORDER IN KORSAKOFF' S PSYCHOSIS A NEUROPATHOLOGICAL AND NEUROPSYCHOLOGICAL INVESTIGATION OF TWO CASES

MEMORY DISORDER IN KORSAKOFF' S PSYCHOSIS A NEUROPATHOLOGICAL AND NEUROPSYCHOLOGICAL... Brain (1979), 102, 749-783 MEMORY DISORDER IN KORSAKOFF'S PSYCHOSIS A NEUROPATHOLOGICAL AND NEUROPSYCHOLOGICAL INVESTIGATION OF TWO CASES by W. G. P. MAIR, E. K. WARRINGTON and L. WEISKRANTZ {From the National Hospital, Queen Square, London WC1N 3BG, and Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford 0X1 3UD) INTRODUCTION TH E most striking feature of Korsakoff s psychosis is a severe and often persistent memory impairment. The patient apparently cannot retain new experiences beyond a few minutes, and there is also a retrograde amnesia which may extend back to events that occurred many years prior to the onset of the illness. There have long been attempts to identify the essential cerebral changes associated with the amnesic syndrome, and the question is also of considerable current interest given the increasing sophistication of both experimental and theoretical analyses of normal human memory function, and of the amnesic syndrome itself. But despite a history of studies going back almost one hundred years, Brierley comments in a recent review (1977) that 'a particular pathological description can be correlated only exceptionally with an amnesia that has been denned with precision. The report of Adams, Collins and Victor (1962) is the only http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Oxford University Press

MEMORY DISORDER IN KORSAKOFF' S PSYCHOSIS A NEUROPATHOLOGICAL AND NEUROPSYCHOLOGICAL INVESTIGATION OF TWO CASES

MAIR, W. G. P.; WARRINGTON, E. K.; WEISKRANTZ, L.
Brain , Volume 102 (4) – Dec 1, 1979
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Publisher
Oxford University Press
Copyright
© Oxford University Press
ISSN
0006-8950
eISSN
1460-2156
DOI
10.1093/brain/102.4.749
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Abstract

Brain (1979), 102, 749-783 MEMORY DISORDER IN KORSAKOFF'S PSYCHOSIS A NEUROPATHOLOGICAL AND NEUROPSYCHOLOGICAL INVESTIGATION OF TWO CASES by W. G. P. MAIR, E. K. WARRINGTON and L. WEISKRANTZ {From the National Hospital, Queen Square, London WC1N 3BG, and Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford 0X1 3UD) INTRODUCTION TH E most striking feature of Korsakoff s psychosis is a severe and often persistent memory impairment. The patient apparently cannot retain new experiences beyond a few minutes, and there is also a retrograde amnesia which may extend back to events that occurred many years prior to the onset of the illness. There have long been attempts to identify the essential cerebral changes associated with the amnesic syndrome, and the question is also of considerable current interest given the increasing sophistication of both experimental and theoretical analyses of normal human memory function, and of the amnesic syndrome itself. But despite a history of studies going back almost one hundred years, Brierley comments in a recent review (1977) that 'a particular pathological description can be correlated only exceptionally with an amnesia that has been denned with precision. The report of Adams, Collins and Victor (1962) is the only

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Brain – Oxford University Press

Published: Dec 1, 1979

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