Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Splenic Salvage Using Biologic Glue

Splenic Salvage Using Biologic Glue Abstract • Fibrin sealant (FS) is a biologic adhesive containing highly concentrated human fibrinogen that is effective in the face-to-face sealing of tissues, and in establishing hemostasis. We evaluated FS in 32 experimentally produced splenic injuries in six adult mongrel dogs. Complete hemostasis was achieved in all animals prior to closure. The dogs were reexplored postoperatively at intervals varying from four hours to six weeks (mean ± SD, 21 ± 20 days). When the dogs were killed, there was no gross evidence of splenic disruption or recurrent bleeding; all of the spleens had developed well-healed capsules. Histologic examination demonstrated a regenerated fibrous capsule extending over the superficial injuries as well as into the deep injuries, without significant inflammatory response. We conclude the following: that FS provides adequate hemostatic control of superficial and deep splenic injuries, FS has good systemic and local compatibility, it can be applied to bleeding parenchymal wounds, it reduces the need for parenchymal sutures that may be traumatic, and it promotes splenic wound healing. (Arch Surg 1984;119:1309-1311) References 1. Morgenstern L, Shapiro SJ: Techniques of splenic conservation . Arch Surg 1979;114:449-454.Crossref 2. Guttman T: Untersuchungen eines Fibrinklebers für die Anwendung in der Chirurgie Peripherer Nerven . Diplomarbeit , Inst F Botanik, Technische Mikroscopie Organ. Rohstofflehre. Vienna, Technische Universität Wien, 1978. 3. Redl H, Schlag G, Dinges H, et al: Background and methods of 'fibrin sealing,' in Winter GD, Gibbons DF, Plenk H (eds): Biomaterials . New York, John Wiley & Sons Inc, 1982, pp 669-676. 4. Morgenstern L: Microcrystalline collagen used in experimental splenic injury: A new surface hemostatic agent . Arch Surg 1974;109:44-47.Crossref 5. Turowski G, Schaadt M, Barthels M, et al: Unterschiedlicher Einfluss von Fibrinogen und Faktor XIII auf das wachstum von Primar und Kulturfibroblasten , in Schimpf F (ed): Fibrinogen, Fibrin, und Fibrinkleber . Stuttgart, FK Schattauer Verlag, 1980, pp 227-237. 6. Knoche H, Schmitt G: Autoradiographische untersuchungen über den Einfluss des Faktors XIII auf die Wundheilung im Tierexperiment . Arzneimittelforsch 1976;26:547-551. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Splenic Salvage Using Biologic Glue

Download PDF
3 pages

Loading next page...
 
/lp/american-medical-association/splenic-salvage-using-biologic-glue-4egFWnQgPn

References (7)

Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1984.01390230075018
Publisher site
See Article on Publisher Site

Abstract

Abstract • Fibrin sealant (FS) is a biologic adhesive containing highly concentrated human fibrinogen that is effective in the face-to-face sealing of tissues, and in establishing hemostasis. We evaluated FS in 32 experimentally produced splenic injuries in six adult mongrel dogs. Complete hemostasis was achieved in all animals prior to closure. The dogs were reexplored postoperatively at intervals varying from four hours to six weeks (mean ± SD, 21 ± 20 days). When the dogs were killed, there was no gross evidence of splenic disruption or recurrent bleeding; all of the spleens had developed well-healed capsules. Histologic examination demonstrated a regenerated fibrous capsule extending over the superficial injuries as well as into the deep injuries, without significant inflammatory response. We conclude the following: that FS provides adequate hemostatic control of superficial and deep splenic injuries, FS has good systemic and local compatibility, it can be applied to bleeding parenchymal wounds, it reduces the need for parenchymal sutures that may be traumatic, and it promotes splenic wound healing. (Arch Surg 1984;119:1309-1311) References 1. Morgenstern L, Shapiro SJ: Techniques of splenic conservation . Arch Surg 1979;114:449-454.Crossref 2. Guttman T: Untersuchungen eines Fibrinklebers für die Anwendung in der Chirurgie Peripherer Nerven . Diplomarbeit , Inst F Botanik, Technische Mikroscopie Organ. Rohstofflehre. Vienna, Technische Universität Wien, 1978. 3. Redl H, Schlag G, Dinges H, et al: Background and methods of 'fibrin sealing,' in Winter GD, Gibbons DF, Plenk H (eds): Biomaterials . New York, John Wiley & Sons Inc, 1982, pp 669-676. 4. Morgenstern L: Microcrystalline collagen used in experimental splenic injury: A new surface hemostatic agent . Arch Surg 1974;109:44-47.Crossref 5. Turowski G, Schaadt M, Barthels M, et al: Unterschiedlicher Einfluss von Fibrinogen und Faktor XIII auf das wachstum von Primar und Kulturfibroblasten , in Schimpf F (ed): Fibrinogen, Fibrin, und Fibrinkleber . Stuttgart, FK Schattauer Verlag, 1980, pp 227-237. 6. Knoche H, Schmitt G: Autoradiographische untersuchungen über den Einfluss des Faktors XIII auf die Wundheilung im Tierexperiment . Arzneimittelforsch 1976;26:547-551.

Journal

Archives of Surgery – American Medical Association

Published: Nov 1, 1984

There are no references for this article.