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Bisphosphonates are increasingly used in conditions such as osteogenesis imperfecta and juvenile osteoporosis. Their potential adverse effects in growing children have been a concern, however, since bisphosphonates inhibit skeletal resorption by suppressing the activity and function of osteoclasts. The authors describe a case of drug-induced osteopetrosis in a 12-year-old boy who had received high doses of pamidronate for nearly three years.
The New England Journal of Medicine – The New England Journal of Medicine
Published: Jul 31, 2003
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