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Risk of incident stroke in patients with Alzheimer disease or vascular dementia

Risk of incident stroke in patients with Alzheimer disease or vascular dementia Risk of incident stroke in patients with Alzheimer disease or vascular dementia ABSTRACT Patrick Imfeld, PhD Michael Bodmer, MD Objective: To explore the risk of ischemic stroke, hemorrhagic stroke, or TIA in patients with Markus Schuerch, PhD Alzheimer disease (AD) or vascular dementia (VD). Susan S. Jick, DSc Methods: We conducted a follow-up study with a nested case-control analysis using the UK-based Christoph R. Meier, PhD General Practice Research Database. We included patients aged 65 years and older with an inci- dent diagnosis of AD or VD between 1998 and 2008 and a comparison group of dementia-free patients. We estimated incidence rates of ischemic stroke, hemorrhagic stroke, or TIA in patients Correspondence to Dr. Meier: with AD, VD, or without dementia, and we calculated odds ratios with 95% confidence intervals [email protected] (CIs) of developing such an outcome in patients with AD or VD, stratified by use of antipsychotic drugs. Results: We followed 6,443 cases with AD, 2,302 with VD, and 9,984 dementia-free patients over time and identified 281 cases with incident ischemic stroke, 139 with hemorrhagic stroke, and 379 with TIA. The incidence rates of ischemic stroke for patients with AD, VD, or no dementia were 4.7/1,000 person-years (PYs) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurology Wolters Kluwer Health

Risk of incident stroke in patients with Alzheimer disease or vascular dementia

Meier, Christoph R.
Neurology , Volume 81 (10) – Sep 1, 2013
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Copyright
© 2013 American Academy of Neurology
ISSN
0028-3878
eISSN
1526-632X
DOI
10.1212/WNL.0b013e3182a35151
pmid
23902701
Publisher site
See Article on Publisher Site

Abstract

Risk of incident stroke in patients with Alzheimer disease or vascular dementia ABSTRACT Patrick Imfeld, PhD Michael Bodmer, MD Objective: To explore the risk of ischemic stroke, hemorrhagic stroke, or TIA in patients with Markus Schuerch, PhD Alzheimer disease (AD) or vascular dementia (VD). Susan S. Jick, DSc Methods: We conducted a follow-up study with a nested case-control analysis using the UK-based Christoph R. Meier, PhD General Practice Research Database. We included patients aged 65 years and older with an inci- dent diagnosis of AD or VD between 1998 and 2008 and a comparison group of dementia-free patients. We estimated incidence rates of ischemic stroke, hemorrhagic stroke, or TIA in patients Correspondence to Dr. Meier: with AD, VD, or without dementia, and we calculated odds ratios with 95% confidence intervals [email protected] (CIs) of developing such an outcome in patients with AD or VD, stratified by use of antipsychotic drugs. Results: We followed 6,443 cases with AD, 2,302 with VD, and 9,984 dementia-free patients over time and identified 281 cases with incident ischemic stroke, 139 with hemorrhagic stroke, and 379 with TIA. The incidence rates of ischemic stroke for patients with AD, VD, or no dementia were 4.7/1,000 person-years (PYs)

Journal

Neurology – Wolters Kluwer Health

Published: Sep 1, 2013

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