Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/annual-reviews/nutritional-and-hormonal-regulation-of-enzymes-in-fat-synthesis-3HK0ADSCvM
References
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
- Publisher
- Annual Reviews
- Copyright
- Copyright © 1998 by Annual Reviews. All rights reserved
- Subject
- Review Articles
- ISSN
- 0199-9885
- eISSN
- 1545-4312
- DOI
- 10.1146/annurev.nutr.18.1.331
- pmid
- 9706228
- Publisher site
- See Article on Publisher Site
Abstract
▪ Abstract The activities of critical enzymes in fatty acid and triacylglycerol biosynthesis are tightly controlled by different nutritional, hormonal, and developmental conditions. Feeding previously fasted animals high-carbohydrate, low-fat diets causes a dramatic induction of enzymes—such as fatty acid synthase (FAS) and mitochondrial glycerol-3-phosphate acyltransferase (GPAT)—involved in fatty acid and triacylglycerol synthesis. During fasting and refeeding, transcription of these two enzymes is coordinately regulated by nutrients and hormones, such as glucose, insulin, glucagon, glucocorticoids, and thyroid hormone. Insulin stimulates transcription of the FAS and mitochondrial GPAT genes, and glucagon antagonizes the insulin effect through the cis -acting elements within the promoters and their bound trans -acting factors. This review discusses advances made in the understanding of the transcriptional regulation of FAS and mitochondrial GPAT genes, with emphasis on elucidation of the mechanisms by which multiple nutrients and hormones achieve their effects.
Journal
Annual Review of Nutrition – Annual Reviews
Published: Jul 1, 1998