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- Publisher
- Springer Journals
- Copyright
- Copyright © 2009 by Current Medicine Group, LLC
- Subject
- Medicine & Public Health; Neurology
- ISSN
- 1528-4042
- eISSN
- 1534-6293
- DOI
- 10.1007/s11910-009-0052-3
- Publisher site
- See Article on Publisher Site
Abstract
TAR DNA-binding protein of about 43 kDa (TDP-43) is the main ubiquitinated peptide in tau-negative frontotemporal lobar degeneration (FTLD). TDP-43 is typically a nuclear protein, and its aggregation and cytoplasmic translocation are thought to represent major steps in the pathogenesis of FTLD due to TDP-43 proteinopathy (FTLD-TDP). Certain clinical syndromes of frontotemporal dementia are preferentially associated with pathologic findings of FTLD-TDP, and TDP-43 pathology represents the connection between FTLD-TDP and amyotrophic lateral sclerosis. Recent advances in clinical, genetic, and pathologic studies of FTLD-TDP and amyotrophic lateral sclerosis have shed light on the potentially pathogenic role of TDP-43 and identified TDP-43 itself as a candidate biomarker for antemortem diagnosis of FTLD-TDP.
Journal
Current Neurology and Neuroscience Reports – Springer Journals
Published: Aug 1, 2009