Access the full text.
Sign up today, get DeepDyve free for 14 days.
Ping-Chih Ho, Katrina Meeth, Y. Tsui, Bhaskar Srivastava, M. Bosenberg, S. Kaech (2014)
Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ.Cancer research, 74 12
Yan Zheng, Greg Delgoffe, C. Meyer, Waipan Chan, J. Powell (2009)
Anergic T Cells Are Metabolically Anergic1The Journal of Immunology, 183
Erika Pearce, M. Poffenberger, Chih-Hao Chang, Russell Jones (2013)
Fueling Immunity: Insights into Metabolism and Lymphocyte FunctionScience, 342
M. Callahan, J. Wolchok, J. Allison (2010)
Anti-CTLA-4 antibody therapy: immune monitoring during clinical development of a novel immunotherapy.Seminars in oncology, 37 5
S. Shiao, Ganesan Ap, Ganesan Ap, H. Rugo, L. Coussens (2011)
Immune microenvironments in solid tumors: new targets for therapy.Genes & development, 25 24
D. Dankort, D. Curley, Robert Cartlidge, Betsy Nelson, A. Karnezis, W. Damsky, M. You, R. DePinho, M. McMahon, M. Bosenberg (2009)
BRafV600E cooperates with Pten silencing to elicit metastatic melanomaNature genetics, 41
H. Braumüller, T. Wieder, E. Brenner, Sonja Assmann, M. Hahn, M. Alkhaled, K. Schilbach, F. Essmann, M. Kneilling, C. Griessinger, Felicia Ranta, S. Ullrich, R. Mocikat, Kilian Braungart, T. Mehra, B. Fehrenbacher, Julia Berdel, H. Niessner, F. Meier, M. Broek, H. Häring, R. Handgretinger, L. Quintanilla‐Martinez, F. Fend, M. Pesic, J. Bauer, L. Zender, M. Schaller, K. Schulze-Osthoff, M. Röcken (2013)
T-helper-1-cell cytokines drive cancer into senescenceNature, 494
P. Ward, C. Thompson (2012)
Metabolic reprogramming: a cancer hallmark even warburg did not anticipate.Cancer cell, 21 3
Tsvetelina Pentcheva-Hoang, E. Corse, J. Allison (2009)
Negative regulators of T‐cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infectionsImmunological Reviews, 229
J. Wolchok, H. Kluger, M. Callahan, M. Postow, N. Rizvi, A. Lesokhin, N. Segal, C. Ariyan, R. Gordon, Kathleen Reed, M. Burke, A. Caldwell, S. Kronenberg, B. Agunwamba, Xiaoling Zhang, I. Lowy, H. Inzunza, W. Feely, C. Horak, Q. Hong, A. Korman, J. Wigginton, A. Gupta, M. Sznol (2013)
Nivolumab plus ipilimumab in advanced melanoma.The New England journal of medicine, 369 2
Shu-Fang Wang, Stéphane Fouquet, M. Chapon, Hélène Salmon, F. Régnier, K. Labroquère, C. Badoual, D. Damotte, P. Validire, E. Maubec, N. Delongchamps, A. Cazes, L. Gibault, M. Garcette, M. Dieu-Nosjean, M. Zerbib, M. Avril, A. Prévost-Blondel, C. Randriamampita, A. Trautmann, N. Bercovici (2011)
Early T Cell Signalling Is Reversibly Altered in PD-1+ T Lymphocytes Infiltrating Human TumorsPLoS ONE, 6
D. Anastasiou, Yimin Yu, William Israelsen, Jian-Kang Jiang, M. Boxer, B. Hong, W. Tempel, S. Dimov, M. Shen, Abhishek Jha, Hua Yang, Katherine Mattaini, Christian Metallo, B. Fiske, K. Courtney, S. Malstrom, Tahsin Khan, C. Kung, A. Skoumbourdis, H. Veith, Noel Southall, M. Walsh, K. Brimacombe, W. Leister, S. Lunt, Zachary Johnson, K. Yen, K. Kunii, S. Davidson, H. Christofk, C. Austin, James Inglese, M. Harris, J. Asara, G. Stephanopoulos, F. Salituro, Shengfang Jin, L. Dang, D. Auld, Hee-won Park, L. Cantley, Craig Thomas, M. Heiden (2012)
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesisNature chemical biology, 8
M. Safford, S. Collins, Michael Lutz, A. Allen, Ching-Tai Huang, J. Kowalski, A. Blackford, M. Horton, C. Drake, R. Schwartz, J. Powell (2005)
Egr-2 and Egr-3 are negative regulators of T cell activationNature Immunology, 6
A. Macintyre, V. Gerriets, Amanda Nichols, Ryan Michalek, Michael Rudolph, D. Deoliveira, S. Anderson, E. Abel, Benny Chen, L. Hale, J. Rathmell (2014)
The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.Cell metabolism, 20 1
M. Heiden, J. Locasale, K. Swanson, H. Sharfi, G. Heffron, D. Amador-Noguez, H. Christofk, G. Wagner, J. Rabinowitz, J. Asara, L. Cantley (2010)
Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating CellsScience, 329
Jianjiong Gao, B. Aksoy, U. Dogrusoz, Gideon Dresdner, Benjamin Gross, S. Sumer, Yichao Sun, A. Jacobsen, Rileen Sinha, E. Larsson, E. Cerami, C. Sander, N. Schultz (2013)
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortalScience Signaling, 6
P. Gubser, G. Bantug, Leyla Razik, M. Fischer, S. Dimeloe, Gideon Hoenger, Bojana Durovic, A. Jauch, C. Hess (2013)
Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switchNature Immunology, 14
P. Gullino, S. Clark, F. Grantham (1964)
THE INTERSTITIAL FLUID OF SOLID TUMORS.Cancer research, 24
R. Schwartz (2003)
T cell anergy.Annual review of immunology, 21
(2012)
Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
E. Cerami, Jianjiong Gao, U. Dogrusoz, Benjamin Gross, S. Sumer, B. Aksoy, A. Jacobsen, Caitlin Byrne, M. Heuer, E. Larsson, Yevgeniy Antipin, B. Reva, A. Goldberg, C. Sander, N. Schultz (2012)
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data.Cancer discovery, 2 5
Ryan Michalek, V. Gerriets, S. Jacobs, A. Macintyre, N. MacIver, Emily Mason, S. Sullivan, Amanda Nichols, J. Rathmell (2011)
Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell SubsetsThe Journal of Immunology, 186
V. Sharov, E. Dremina, N. Galeva, T. Williams, C. Schöneich (2006)
Quantitative mapping of oxidation-sensitive cysteine residues in SERCA in vivo and in vitro by HPLC-electrospray-tandem MS: selective protein oxidation during biological aging.The Biochemical journal, 394 Pt 3
P. Borge, B. Wolf (2003)
Insulin Receptor Substrate 1 Regulation of Sarco-endoplasmic Reticulum Calcium ATPase 3 in Insulin-secreting β-Cells*The Journal of Biological Chemistry, 278
S. Feske, E. Skolnik, M. Prakriya (2012)
Ion channels and transporters in lymphocyte function and immunityNature Reviews Immunology, 12
J. Blagih, F. Coulombe, E. Vincent, Fanny Dupuy, Gabriela Galicia-Vázquez, E. Yurchenko, T. Raissi, G. Windt, B. Viollet, Erika Pearce, J. Pelletier, C. Piccirillo, C. Krawczyk, M. Divangahi, Russell Jones (2015)
The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo.Immunity, 42 1
Ming Yang, T. Soga, Patrick Pollard (2013)
Oncometabolites: linking altered metabolism with cancer.The Journal of clinical investigation, 123 9
Ruoning Wang, C. Dillon, L. Shi, S. Milasta, R. Carter, D. Finkelstein, L. McCormick, Patrick Fitzgerald, H. Chi, Joshua Munger, D. Green (2011)
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation.Immunity, 35 6
H. Haslene-Hox, E. Oveland, Kaja Berg, Odd Kolmannskog, K. Woie, H. Salvesen, O. Tenstad, H. Wiig (2011)
A New Method for Isolation of Interstitial Fluid from Human Solid Tumors Applied to Proteomic Analysis of Ovarian Carcinoma TissuePLoS ONE, 6
Chih-Hao Chang, Jonathan Curtis, L. Maggi, B. Faubert, A. Villarino, David O’Sullivan, S. Huang, G. Windt, J. Blagih, J. Qiu, J. Weber, E. Pearce, Russell Jones, Erika Pearce (2013)
Posttranscriptional Control of T Cell Effector Function by Aerobic GlycolysisCell, 153
F. Qin, D. Siwik, S. Lancel, Jingmei Zhang, Gabriela Kuster, I. Luptak, Lei Wang, Xiaoyong Tong, Y. Kang, Richard Cohen, Wilson Colucci (2013)
Hydrogen Peroxide–Mediated SERCA Cysteine 674 Oxidation Contributes to Impaired Cardiac Myocyte Relaxation in Senescent Mouse HeartJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2
I. Mellman, G. Coukos, G. Dranoff (2011)
Cancer immunotherapy comes of ageNature, 480
A. Doedens, Anthony Phan, M. Stradner, Jessica Fujimoto, Jessica Nguyen, E. Yang, R. Johnson, A. Goldrath (2013)
Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigenNature Immunology, 14
Mathangi Srinivasan, K. Frauwirth (2007)
Reciprocal NFAT1 and NFAT2 Nuclear Localization in CD8+ Anergic T Cells Is Regulated by Suboptimal Calcium Signaling1The Journal of Immunology, 179
Ping-Chih Ho, Ya-Shan Chuang, Chen-Hsiang Hung, Li-Na Wei (2011)
Cytoplasmic receptor-interacting protein 140 (RIP140) interacts with perilipin to regulate lipolysis.Cellular signalling, 23 8
Xiaojing Liu, Zheng Ser, J. Locasale (2014)
Development and Quantitative Evaluation of a High-Resolution Metabolomics TechnologyAnalytical Chemistry, 86
R. Parry, J. Chemnitz, K. Frauwirth, A. Lanfranco, Inbal Braunstein, Sumire Kobayashi, P. Linsley, C. Thompson, J. Riley (2004)
CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct MechanismsMolecular and Cellular Biology, 25
D. Finlay, E. Rosenzweig, Linda Sinclair, C. Feijoo-Carnero, J. Hukelmann, J. Rolf, A. Panteleyev, K. Okkenhaug, D. Cantrell (2012)
PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cellsThe Journal of Experimental Medicine, 209
E. Wherry (2011)
T cell exhaustionNature Immunology, 12
M. Izquierdo, D. Cantrell (1992)
T-cell activation.Trends in cell biology, 2 9
H. Ying, Alec Kimmelman, C. Lyssiotis, Sujun Hua, Gerald Chu, Eliot Fletcher-Sananikone, J. Locasale, Jaekyoung Son, Hailei Zhang, Jonathan Coloff, Haiyan Yan, Wei Wang, Shujuan Chen, Andrea Viale, Hongwu Zheng, Ji-hye Paik, Carol Lim, A. Guimaraes, Eric S. Martin, Jeffery Chang, A. Hezel, Samuel Perry, Jian Hu, Boyi Gan, Yonghong Xiao, J. Asara, Ralph Weissleder, Y. Alan Wang, Lynda Chin, Lewis Cantley, Ronald DePinho (2012)
Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose MetabolismCell, 149
L. Baitsch, Silvia Fuertes-Marraco, A. Legat, C. Meyer, D. Speiser (2012)
The three main stumbling blocks for anticancer T cells.Trends in immunology, 33 7
N. MacIver, Ryan Michalek, J. Rathmell (2013)
Metabolic regulation of T lymphocytes.Annual review of immunology, 31
K. Frauwirth, J. Riley, M. Harris, R. Parry, J. Rathmell, D. Plas, R. Elstrom, C. June, C. Thompson (2002)
The CD28 signaling pathway regulates glucose metabolism.Immunity, 16 6
Amy Moran, Keli Holzapfel, Yan Xing, Nicole Cunningham, J. Maltzman, J. Punt, K. Hogquist (2011)
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouseThe Journal of Experimental Medicine, 208
S. Maude, N. Frey, P. Shaw, R. Aplenc, D. Barrett, N. Bunin, A. Chew, V. Gonzalez, Zhaohui Zheng, S. Lacey, Y. Mahnke, J. Melenhorst, S. Rheingold, A. Shen, D. Teachey, B. Levine, C. June, D. Porter, S. Grupp (2014)
Chimeric antigen receptor T cells for sustained remissions in leukemia.The New England journal of medicine, 371 16
Smith-Garvin (2009)
T cell activationAnnu. Rev. Immunol., 27
Matthew Staron, Simon Gray, H. Marshall, I. Parish, Jonathan Chen, Curtis Perry, Guoliang Cui, Ming Li, S. Kaech (2014)
The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection.Immunity, 41 5
D. Hanahan, R. Weinberg (2011)
Hallmarks of Cancer: The Next GenerationCell, 144
C. Cham, Grégory Driessens, James O’Keefe, T. Gajewski (2008)
Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cellsEuropean Journal of Immunology, 38
Cell – Unpaywall
Published: Aug 27, 2015
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.