Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryos.

Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in... Downloaded from genesdev.cshlp.org on December 5, 2021 - Published by Cold Spring Harbor Laboratory Press Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryos U. Str~ihle, P. Blader, D. Henrique, 1 and P.W. Ingham Imperial Cancer Research Fund (ICRF), Developmental Biology Unit, Department of Zoology, 1Molecular Embryology Laboratory and Developmental Genetics Laboratory, University of Oxford, Oxford, OX1 3PS UK Here, we report the cloning of a cDNA from zebrafish encoding a member of the fork head/HNF3 gene family. The gene, which we have called Axial, begins to be expressed just before gastrulation in a narrow region on the dorsal side of the embryo, the fish equivalent of the amphibian organizer. Expression can be detected in the involuted cells comprising the mesendoderm of the developing axis. At the end of gastrulation expression is turned on in the ventral neural plate in cells adjacent to the Axial-expressing mesodermal cells. Thus, Axial appears to be a target of both mesoderm induction and neural induction, leading to expression in cells of all three germ layers along the developing axis. Like the Brachyury gene, Axia/is strongly induced by activin A, suggesting a role for endogenous activins http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryos.

Strahle, U; Blader, P; Henrique, D; Ingham, P W
Genes & Development – Jul 1, 1993
Download PDF
12 pages

Loading next page...
 
/lp/unpaywall/axial-a-zebrafish-gene-expressed-along-the-developing-body-axis-shows-2j2roDy893

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.7.7b.1436
Publisher site
See Article on Publisher Site

Abstract

Downloaded from genesdev.cshlp.org on December 5, 2021 - Published by Cold Spring Harbor Laboratory Press Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryos U. Str~ihle, P. Blader, D. Henrique, 1 and P.W. Ingham Imperial Cancer Research Fund (ICRF), Developmental Biology Unit, Department of Zoology, 1Molecular Embryology Laboratory and Developmental Genetics Laboratory, University of Oxford, Oxford, OX1 3PS UK Here, we report the cloning of a cDNA from zebrafish encoding a member of the fork head/HNF3 gene family. The gene, which we have called Axial, begins to be expressed just before gastrulation in a narrow region on the dorsal side of the embryo, the fish equivalent of the amphibian organizer. Expression can be detected in the involuted cells comprising the mesendoderm of the developing axis. At the end of gastrulation expression is turned on in the ventral neural plate in cells adjacent to the Axial-expressing mesodermal cells. Thus, Axial appears to be a target of both mesoderm induction and neural induction, leading to expression in cells of all three germ layers along the developing axis. Like the Brachyury gene, Axia/is strongly induced by activin A, suggesting a role for endogenous activins

Journal

Genes & Development – Unpaywall

Published: Jul 1, 1993

There are no references for this article.