Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Influenza Pathogenesis and Control - Volume IIThe Effector T Cell Response to Influenza Infection

Influenza Pathogenesis and Control - Volume II: The Effector T Cell Response to Influenza Infection [Influenza virus infection induces a potent initial innate immune response, which serves to limit the extent of viral replication and virus spread. However, efficient (and eventual) viral clearance within the respiratory tract requires the subsequent activation, rapid proliferation, recruitment, and expression of effector activities by the adaptive immune system, consisting of antibody producing B cells and influenza-specific T lymphocytes with diverse functions. The ensuing effector activities of these T lymphocytes ultimately determine (along with antibodies) the capacity of the host to eliminate the viruses and the extent of tissue damage. In this review, we describe this effector T cell response to influenza virus infection. Based on information largely obtained in experimental settings (i.e., murine models), we will illustrate the factors regulating the induction of adaptive immune T cell responses to influenza, the effector activities displayed by these activated T cells, the mechanisms underlying the expression of these effector mechanisms, and the control of the activation/differentiation of these T cells, in situ, in the infected lungs.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Influenza Pathogenesis and Control - Volume IIThe Effector T Cell Response to Influenza Infection

Part of the Current Topics in Microbiology and Immunology Book Series (volume 386)
Editors: Oldstone, Michael B. A.; Compans, Richard W.
Hufford, Matthew M; Kim, Taeg S; Sun, Jie; Braciale, Thomas J
Influenza Pathogenesis and Control - Volume II — Jul 18, 2014
Download PDF
32 pages

Loading next page...
 
/lp/springer-journals/influenza-pathogenesis-and-control-volume-ii-the-effector-t-cell-2dRu5dgHW0

References (154)

Publisher
Springer International Publishing
Copyright
© Springer International Publishing Switzerland 2015
ISBN
978-3-319-11157-5
Pages
423–455
DOI
10.1007/82_2014_397
Publisher site
See Chapter on Publisher Site

Abstract

[Influenza virus infection induces a potent initial innate immune response, which serves to limit the extent of viral replication and virus spread. However, efficient (and eventual) viral clearance within the respiratory tract requires the subsequent activation, rapid proliferation, recruitment, and expression of effector activities by the adaptive immune system, consisting of antibody producing B cells and influenza-specific T lymphocytes with diverse functions. The ensuing effector activities of these T lymphocytes ultimately determine (along with antibodies) the capacity of the host to eliminate the viruses and the extent of tissue damage. In this review, we describe this effector T cell response to influenza virus infection. Based on information largely obtained in experimental settings (i.e., murine models), we will illustrate the factors regulating the induction of adaptive immune T cell responses to influenza, the effector activities displayed by these activated T cells, the mechanisms underlying the expression of these effector mechanisms, and the control of the activation/differentiation of these T cells, in situ, in the infected lungs.]

Published: Jul 18, 2014

Keywords: Major Histocompatiblity Complex; Influenza Infection; Infected Lung; Adaptive Immune Cell; Antiviral Immunity

There are no references for this article.