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Cellular transformation by human T-cell leukemia virus type I

Cellular transformation by human T-cell leukemia virus type I AbstractHuman T-cell leukemia virus type I (HTLV-I) is an oncogenic retrovirus that was isolated in 1980 from a patient with adult T-cell leukemia. From numerous experiments using infected patient T-cells, transgenic mice and tissue culture transformation assays, the Tax protein has been determined to be the transforming component of HTLV-I. Tax-mediated transformation is linked to its ability to transcriptionally regulate the expression of cellular genes involved in growth and proliferation. Ultimately, unregulated and continued activation of these important growth modulating genes by Tax leads to transformation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png FEMS Microbiology Letters Oxford University Press

Cellular transformation by human T-cell leukemia virus type I

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References (58)

Publisher
Oxford University Press
Copyright
Copyright © 1996 Federation of European Microbiological Societies. Published by Elsevier Science B.V.
ISSN
0378-1097
eISSN
1574-6968
DOI
10.1111/j.1574-6968.1996.tb08322.x
pmid
8764470
Publisher site
See Article on Publisher Site

Abstract

AbstractHuman T-cell leukemia virus type I (HTLV-I) is an oncogenic retrovirus that was isolated in 1980 from a patient with adult T-cell leukemia. From numerous experiments using infected patient T-cells, transgenic mice and tissue culture transformation assays, the Tax protein has been determined to be the transforming component of HTLV-I. Tax-mediated transformation is linked to its ability to transcriptionally regulate the expression of cellular genes involved in growth and proliferation. Ultimately, unregulated and continued activation of these important growth modulating genes by Tax leads to transformation.

Journal

FEMS Microbiology LettersOxford University Press

Published: Jul 17, 1996

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