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Suppression by TFR cells leads to durable and selective inhibition of B cell effector function

Suppression by TFR cells leads to durable and selective inhibition of B cell effector function Follicular regulatory T cells (TFR cells) inhibit follicular helper T cell (TFH cell)-mediated antibody production. Sharpe and colleagues show that TFR cells induce a distinct suppressive state in TFH cells and B cells that can be reversed by the cytokine IL-21. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Immunology Springer Journals

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References (54)

Publisher
Springer Journals
Copyright
Copyright © 2016 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Subject
Biomedicine; Biomedicine, general; Immunology; Infectious Diseases
ISSN
1529-2908
eISSN
1529-2916
DOI
10.1038/ni.3578
Publisher site
See Article on Publisher Site

Abstract

Follicular regulatory T cells (TFR cells) inhibit follicular helper T cell (TFH cell)-mediated antibody production. Sharpe and colleagues show that TFR cells induce a distinct suppressive state in TFH cells and B cells that can be reversed by the cytokine IL-21.

Journal

Nature ImmunologySpringer Journals

Published: Oct 3, 2016

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