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References (27)
-
Christian Pike, A. Walencewicz, Charles Glabe, Carl Cotman (1991)
Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures.European journal of pharmacology, 207 4
-
R. Castellani, George Perry (2013)
Molecular Pathology of Alzheimer's Disease -
C. Hilbich, B. Kisters-Woike, J. Reed, C. Masters, K. Beyreuther (1991)
Human and rodent sequence analogs of Alzheimer's amyloid beta A4 share similar properties and can be solubilized in buffers of pH 7.4.European journal of biochemistry, 201 1
-
P. May, B. Gitter, D. Waters, L. Simmons, G. Becker, Jennifer Small, P. Robison (1992)
β-amyloid peptide in vitro toxicity: Lot-to-lot variabilityNeurobiology of Aging, 13
-
J. Busciglio, A. Lorenzo, B. Yankner (1992)
Methodological variables in the assessment of beta amyloid neurotoxicityNeurobiology of Aging, 13
-
Paul Fraser, J. Nguyen, H. Inouye, W. Surewicz, Dennis Selkoe, M. Podlisny, Daniel Kirschner (1992)
Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein.Biochemistry, 31 44
-
Simmons (1993)
Secondary structure of amyloid-beta peptide correlates with neurotoxic activity in vitroSoc. Neurosci. Abs, 19
-
G. Cooper, A. Willis, A. Clark, R. Turner, Robert Sim, K. Reid (1987)
Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients.Proceedings of the National Academy of Sciences of the United States of America, 84 23
-
Ambikaipakan Balasubramaniam, V. Renugopalakrishnan, M. Stein, Josef Fischer, W. Chance (1991)
Syntheses, structures and anorectic effects of human and rat amylinPeptides, 12
-
B. Yankner, L. Duffy, Daniel Kirschner (1990)
Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides.Science, 250 4978
-
E. Johnstone, M. Chaney, F. Norris, Rhett Pascual, S. Little (1991)
Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis.Brain research. Molecular brain research, 10 4
-
L. McLean, A. Balasubramaniam (1992)
Promotion of beta-structure by interaction of diabetes associated polypeptide (amylin) with phosphatidylcholine.Biochimica et biophysica acta, 1122 3
-
C. Hilbich, B. Kisters-Woike, J. Reed, C. Masters, K. Beyreuther (1992)
Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides.Journal of molecular biology, 228 2
-
J. Maggio, E. Stimson, J. Ghilardi, C. Allen, C. Dahl, D. Whitcomb, S. Vigna, H. Vinters, M. Labenski, P. Mantyh (1992)
Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide.Proceedings of the National Academy of Sciences of the United States of America, 89
-
P. Westermark, C. Wernstedt, E. Wilander, D. Hayden, T. O'Brien, K. Johnson (1987)
Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.Proceedings of the National Academy of Sciences of the United States of America, 84 11
-
P. Westermark, U. Engström, K. Johnson, G. Westermark, C. Betsholtz (1990)
Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation.Proceedings of the National Academy of Sciences of the United States of America, 87 13
-
M. Mattson, B. Cheng, D. Davis, K. Bryant, I. Lieberburg, R. Rydel (1992)
beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity, 12
-
D. Selkoe (1991)
The molecular pathology of Alzheimer's diseaseNeuron, 6
-
B. Shivers, C. Hilbich, G. Multhaup, M. Salbaum, K. Beyreuther, P. Seeburg (1988)
Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.The EMBO Journal, 7
-
J. Asai, M. Nakazato, K. Kangawa, S. Matsukura, H. Matsuo (1989)
Isolation and sequence determination of rat islet amyloid polypeptide.Biochemical and biophysical research communications, 164 1
-
T. Dyrks, E. Dyrks, Colin Masters, K. Beyreuther (1993)
Amyloidogenicity of rodent and human βA4 sequencesFEBS Letters, 324
-
L. Simmons, P. May, K. Tomaselli, R. Rydel, Kimberly Fuson, E. Brigham, S. Wright, I. Lieberburg, G. Becker, D. Brems (1994)
Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro.Molecular pharmacology, 45 3
-
M. Gasset, M. Baldwin, D. Lloyd, J. Gabriel, D. Holtzman, F. Cohen, R. Fletterick, S. Prusiner (1992)
Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.Proceedings of the National Academy of Sciences of the United States of America, 89 22
-
C. Pike, D. Burdick, A. Walencewicz, C. Glabe, C. Cotman (1993)
Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state, 13
-
G. Forloni, N. Angeretti, R. Chiesa, E. Monzani, M. Salmona, O. Bugiani, F. Tagliavini (1993)
Neurotoxicity of a prion protein fragmentNature, 362
-
M. Mattson, K. Tomaselli, R. Rydel (1993)
Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGFBrain Research, 621
-
J. Campistol, M. Skinner (1993)
β2‐Microglobulin Amyloidosis: An OverviewSeminars in Dialysis, 6
- Publisher
- Wiley
- Copyright
- Copyright © 1993 Wiley Subscription Services
- ISSN
- 0022-3042
- eISSN
- 1471-4159
- DOI
- 10.1111/j.1471-4159.1993.tb07480.x
- Publisher site
- See Article on Publisher Site
Abstract
Amylin, a 37‐amino‐acid amyloidogenic peptide, bears biophysical similarities to the amyloid‐β peptide (Aβ) deposited in Alzheimer's disease. Using embryonic rat hippocampal cultures we tested whether amylin induces neurotoxicity similar to that previously observed with Aβ(1–40). Treatment with human amylin (1–37) resulted in prominent toxicity as assessed by phasecontrast microscopy and quantification of lactate dehydrogenase in the medium. Amylin‐induced neurotoxicity was morphologically similar to that induced by Aβ(1–40). In contrast, the nonamyloidogenic rat amylin showed negligible neurotoxicity despite having 95% sequence similarity to human amylin. Only full‐length human amylin was toxic; various amylin peptide fragments including amino acid residues 20–29 were nontoxic at similar concentrations. These studies suggest that unrelated amyloidogenic peptides like human amylin and Aβ can adopt a similar neurotoxic conformation in vitro. Similar conformation‐dependent neurotoxicity may drive the prominent neurite degeneration around compacted but not diffuse deposits of Aβ in Alzheimer's disease.
Journal
Journal of Neurochemistry – Wiley
Published: Jan 1, 1993
Keywords: ; ; ; ;