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- Publisher
- Wiley
- Copyright
- Copyright © 1997 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 1742-464X
- eISSN
- 1742-4658
- DOI
- 10.1111/j.1432-1033.1997.t01-4-00001.x
- Publisher site
- See Article on Publisher Site
Abstract
Protein kinase C (PKC) isoenzymes are involved in diverse cellular functions, including differentiation, growth control, tumor promotion, and cell death. In recent years, evidence has began to emerge suggesting a role for PKC in cell cycle control. A paper published recently, demonstrating a functional link between PKC and cell cycle control in yeast (Marini, N. J., Meldrum, E., Buehrer, B., Hubberstey, A. V., Stone, D. E., Traynor‐Kaplan, A. & Reed, S. I. (1996) EMBO J. 15, 3040–3052), strengthens this data. Thus, the existence of cell‐cycle‐regulated pathways involving PKC in both yeast and mammals indicate that PKC may be a conserved regulator of cell cycle events that links signal transduction pathways and the cell‐cycle machinery. In this paper, we will review current data on the cell cycle components that are targets for PKC regulation.
Journal
FEBS Journal – Wiley
Published: Aug 1, 1997
Keywords: ; ; ; ; ; ; ; ; ;