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Participation in a Clinical Trial Enhances Adherence and Persistence to Treatment A Retrospective Cohort Study

Participation in a Clinical Trial Enhances Adherence and Persistence to Treatment A Retrospective... Participation in a Clinical Trial Enhances Adherence and Persistence to Treatment A Retrospective Cohort Study Hein A.W. van Onzenoort, Frederique E. Menger, Cees Neef, Willem J. Verberk, Abraham A. Kroon, Peter W. de Leeuw, Paul-Hugo M. van der Kuy Abstract—Poor adherence to treatment is one of the major determinants of an uncontrolled blood pressure. Participation in a clinical trial may increase patient’s adherence to treatment. This prompted us to investigate adherence and persistence profiles in patients with hypertension who had participated in a clinical trial, by collecting pharmacy refill data before, during, and after participation in the trial. Pharmacy refill data of 182 patients with hypertension who participated in the Home Versus Office Blood Pressure Measurements: Reduction of Unnecessary Treatment Study between 2001 and 2005 were obtained from 1999 until 2010. Refill adherence to treatment was compared for the periods before, during, and after this trial. Persistence to medication was investigated for the period after termination of the trial. Refill data were available for 22 600 prescriptions. Participation into the trial significantly increased refill adherence, from 90.6% to 95.6% (P0.001). After the trial period, refill adherence decreased again to 91.8% (P0.001), which did not differ from the adherence before http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hypertension Wolters Kluwer Health

Participation in a Clinical Trial Enhances Adherence and Persistence to Treatment A Retrospective Cohort Study

van der Kuy, Paul-Hugo M.
Hypertension , Volume 58 (4) – Oct 1, 2011
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Copyright
© 2011 American Heart Association, Inc.
ISSN
0194-911X
eISSN
1524-4563
DOI
10.1161/HYPERTENSIONAHA.111.171074
pmid
21825228
Publisher site
See Article on Publisher Site

Abstract

Participation in a Clinical Trial Enhances Adherence and Persistence to Treatment A Retrospective Cohort Study Hein A.W. van Onzenoort, Frederique E. Menger, Cees Neef, Willem J. Verberk, Abraham A. Kroon, Peter W. de Leeuw, Paul-Hugo M. van der Kuy Abstract—Poor adherence to treatment is one of the major determinants of an uncontrolled blood pressure. Participation in a clinical trial may increase patient’s adherence to treatment. This prompted us to investigate adherence and persistence profiles in patients with hypertension who had participated in a clinical trial, by collecting pharmacy refill data before, during, and after participation in the trial. Pharmacy refill data of 182 patients with hypertension who participated in the Home Versus Office Blood Pressure Measurements: Reduction of Unnecessary Treatment Study between 2001 and 2005 were obtained from 1999 until 2010. Refill adherence to treatment was compared for the periods before, during, and after this trial. Persistence to medication was investigated for the period after termination of the trial. Refill data were available for 22 600 prescriptions. Participation into the trial significantly increased refill adherence, from 90.6% to 95.6% (P0.001). After the trial period, refill adherence decreased again to 91.8% (P0.001), which did not differ from the adherence before

Journal

Hypertension – Wolters Kluwer Health

Published: Oct 1, 2011

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