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Antioxidants and Cancer. IV. Initiating Activity of Malonaldehyde as a Carcinogen

Antioxidants and Cancer. IV. Initiating Activity of Malonaldehyde as a Carcinogen Summary Malonaldehyde was applied once to the shaved backs of mice. After daily treatment with 0.1% croton oil, 52% of the mice had tumors at 30 weeks. In the same experiment, other mice were treated once with β-propiolactone, glycidaldehyde, or 7,12-dimethylbenz- [a]anthracene (DMBA), and then daily with croton oil. These animals had 44, 40, and 95% tumors, respectively, at 30 weeks. Twelve mg malonaldehyde applied daily proved toxic, sometimes fatally so. Five animals also had carcinomas of their internal organs. After daily treatment with 0.36 mg malonaldehyde, no animals died of carcinoma. The predicted reactivity of malonaldehyde was confirmed; after 1 hour, only 1.9% of the applied malonaldehyde was detectable. All skin treated with DMBA, benzo[a]pyrene, and 3-methylcholanthrene had increased malonaldehyde levels. This content is only available as a PDF. Author notes 2 Department of Biochemistry, The Cleveland Clinic Foundation and The Cleveland Clinic Educational Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44106. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JNCI: Journal of the National Cancer Institute Oxford University Press

Antioxidants and Cancer. IV. Initiating Activity of Malonaldehyde as a Carcinogen

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References (28)

Publisher
Oxford University Press
ISSN
0027-8874
eISSN
1460-2105
DOI
10.1093/jnci/53.6.1771
Publisher site
See Article on Publisher Site

Abstract

Summary Malonaldehyde was applied once to the shaved backs of mice. After daily treatment with 0.1% croton oil, 52% of the mice had tumors at 30 weeks. In the same experiment, other mice were treated once with β-propiolactone, glycidaldehyde, or 7,12-dimethylbenz- [a]anthracene (DMBA), and then daily with croton oil. These animals had 44, 40, and 95% tumors, respectively, at 30 weeks. Twelve mg malonaldehyde applied daily proved toxic, sometimes fatally so. Five animals also had carcinomas of their internal organs. After daily treatment with 0.36 mg malonaldehyde, no animals died of carcinoma. The predicted reactivity of malonaldehyde was confirmed; after 1 hour, only 1.9% of the applied malonaldehyde was detectable. All skin treated with DMBA, benzo[a]pyrene, and 3-methylcholanthrene had increased malonaldehyde levels. This content is only available as a PDF. Author notes 2 Department of Biochemistry, The Cleveland Clinic Foundation and The Cleveland Clinic Educational Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44106.

Journal

JNCI: Journal of the National Cancer Institute – Oxford University Press

Published: Dec 1, 1974

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