Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia

Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards... Letters to the Editor Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia Leukemia (2015) 29, 981–984; doi:10.1038/leu.2014.320 (Figure 1c, Supplementary Figure 4C), providing a feasible explanation for the increased efficacy of ABT-737 and ABT-199. Recently, it was described that in CLL patients the treatment response to ABT-263, an orally available analog to ABT-737, was Chronic lymphocytic leukemia (CLL) is characterized by a distinct dependent on the ratio between Mcl-1 and the proapoptotic Bcl-2 chemoresistance, which is thought to be caused by microenviron- protein BIM. Taking this observation into consideration, we mental stimulation. In particular, the pivotal role of environmental determined the expression of BIM and Mcl-1 (Supplementary survival cues involving signaling downstream to CD40 or B-cell Figure 4D) and calculated the resulting BIM:Mcl-1 ratio, which was receptor in CLL survival and chemoresponse is well characterized. significantly increased in hypoxia (Supplementary Figure 4E). These In contrast, despite its evident importance in solid tumors, the findings correlate with the observations in patients, indicating that impact of hypoxia on CLL is only poorly understood. Recent our in vitro model might reflect the situation in vivo. reports showed that oxygen levels are reduced down http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Leukemia Springer Journals

Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia

Download PDF
4 pages

Loading next page...
 
/lp/springer-journals/hypoxia-induced-p38-mapk-activation-reduces-mcl-1-expression-and-1XmQztu57C

References (16)

Publisher
Springer Journals
Copyright
Copyright © 2015 by Macmillan Publishers Limited
Subject
Medicine & Public Health; Medicine/Public Health, general; Internal Medicine; Intensive / Critical Care Medicine; Cancer Research; Oncology; Hematology
ISSN
0887-6924
eISSN
1476-5551
DOI
10.1038/leu.2014.320
Publisher site
See Article on Publisher Site

Abstract

Letters to the Editor Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia Leukemia (2015) 29, 981–984; doi:10.1038/leu.2014.320 (Figure 1c, Supplementary Figure 4C), providing a feasible explanation for the increased efficacy of ABT-737 and ABT-199. Recently, it was described that in CLL patients the treatment response to ABT-263, an orally available analog to ABT-737, was Chronic lymphocytic leukemia (CLL) is characterized by a distinct dependent on the ratio between Mcl-1 and the proapoptotic Bcl-2 chemoresistance, which is thought to be caused by microenviron- protein BIM. Taking this observation into consideration, we mental stimulation. In particular, the pivotal role of environmental determined the expression of BIM and Mcl-1 (Supplementary survival cues involving signaling downstream to CD40 or B-cell Figure 4D) and calculated the resulting BIM:Mcl-1 ratio, which was receptor in CLL survival and chemoresponse is well characterized. significantly increased in hypoxia (Supplementary Figure 4E). These In contrast, despite its evident importance in solid tumors, the findings correlate with the observations in patients, indicating that impact of hypoxia on CLL is only poorly understood. Recent our in vitro model might reflect the situation in vivo. reports showed that oxygen levels are reduced down

Journal

Leukemia – Springer Journals

Published: Nov 7, 2014

There are no references for this article.