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JCRP2802_92-98 7/3/08 20:19 Page 92 The Role of Fish Oil in Arrhythmia Prevention Rishi G. Anand, MD, Mohi Alkadri, MD, Carl J. Lavie, MD, and Richard V. Milani, MD ■ Numerous epidemiological studies, case-control series, and randomized KEY WORDS trials have demonstrated the ability of fish oil to reduce major cardiovas- cular events, particularly sudden cardiac death and all-cause mortality. arrhythmia We discuss the potential benefits of fish oil therapy to improve overall autonomic tone and potentially reduce the risk of major ventricular and fish oil atrial arrhythmias. Specifically, this review focuses on how fish oil thera- py has performed in 3 primary prevention trials in patients with prevention implantable cardioverter defibrillators, reviews the effects that fish oil has on the autonomic nervous system, focuses on the use of fish oil as a novel therapy for atrial fibrillation, and revisits other beneficial properties of fish oil (ie, ability to lower serum triglycerides, anti-inflammatory effects, and possible improvements in arterial pressure/diastolic function). We also discuss the safety profile of fish oil, including effects on bleeding time and bleeding complications as well as provide commentary regard- ing fish oil supplementation in light of increasing contaminants contained in fish. In summary, any
Journal of Cardiopulmonary Rehabilitation and Prevention – Wolters Kluwer Health
Published: Mar 1, 2008
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