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Control of mRNA translation and stability in haematopoietic cells: The function of hnRNPs K and E1/E2

Control of mRNA translation and stability in haematopoietic cells: The function of hnRNPs K and... Summry— Studies on the post‐transcriptional regulation of gene expression in haematopoietic cells have uncovered that a subfamily of heterogeneous nuclear ribonucleoproteins (hnRNPs) is involved in cytoplasmic gene regulation. HnRNP K and hnRNP E1/E2 share a common structural motif, the hnRNP K homology (KH) domain, which provides a structural basis for mRNA binding. The KH‐domains are components of a modular system, which enables these proteins to engage in both, protein/nucleic acid and protein/protein interactions, the latter generating connectivity to cell signalling events. As components of different mRNA‐protein complexes, hnRNP K and hnRNP E1/E2 function in the control of mRNA translation and mRNA stability in haematopoietic cell differentiation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biology of the Cell Wiley

Control of mRNA translation and stability in haematopoietic cells: The function of hnRNPs K and E1/E2

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References (51)

Publisher
Wiley
Copyright
2004 Société Française des Microscopies and Société Biologie Cellulaire de France
ISSN
0248-4900
eISSN
1768-322X
DOI
10.1016/j.biolcel.2004.03.010
Publisher site
See Article on Publisher Site

Abstract

Summry— Studies on the post‐transcriptional regulation of gene expression in haematopoietic cells have uncovered that a subfamily of heterogeneous nuclear ribonucleoproteins (hnRNPs) is involved in cytoplasmic gene regulation. HnRNP K and hnRNP E1/E2 share a common structural motif, the hnRNP K homology (KH) domain, which provides a structural basis for mRNA binding. The KH‐domains are components of a modular system, which enables these proteins to engage in both, protein/nucleic acid and protein/protein interactions, the latter generating connectivity to cell signalling events. As components of different mRNA‐protein complexes, hnRNP K and hnRNP E1/E2 function in the control of mRNA translation and mRNA stability in haematopoietic cell differentiation.

Journal

Biology of the CellWiley

Published: Aug 1, 2004

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