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Tumour angiogenesisAdvunc. Cancer Res., 19
- Publisher
- Wiley
- Copyright
- Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company
- ISSN
- 0020-7136
- eISSN
- 1097-0215
- DOI
- 10.1002/ijc.2910230115
- Publisher site
- See Article on Publisher Site
Abstract
Tumour angiogenesis factor (TAF) has been extracted from a variety of animal and human tumours. Its ability to induce neovascularization in two bioassays, viz. rat air‐sac and chick chorio‐allantoic membrane, is demonstrated. Similar extracts from normal tissues fail to induce angiogenesis. TAF extracts have been used to raise a xenogeneic antiserum, the specificity of which was investigated using classical immunological methods. Its ability to neutralize the biological activity of TAF using the two in vivo assays, was also demonstrated.
Journal
International Journal of Cancer – Wiley
Published: Jan 15, 1979