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Limited efficacy of propranolol on the reconsolidation of fear memories

Limited efficacy of propranolol on the reconsolidation of fear memories Downloaded from learnmem.cshlp.org on October 15, 2021 - Published by Cold Spring Harbor Laboratory Press Research Limited efficacy of propranolol on the reconsolidation of fear memories 1 1,2,3 Elizaveta V. Muravieva and Cristina M. Alberini 1 2 Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA; Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA Previous studies suggested that the b-adrenergic receptor antagonist propranolol might be a novel, potential treatment for post-traumatic stress disorder (PTSD). This hypothesis stemmed mainly from rodent studies showing that propranolol interferes with the reconsolidation of Pavlovian fear conditioning (FC). However, subsequent investigations in humans have produced controversial evidence about the effect of propranolol on fear memories and an effect on PTSD symptomatology has yet to be reported. Thus, it remains to be established whether propranolol interferes with the reconsolidation of fear memories at large. To address this question, we tested the effect of systemic injections of propranolol administered before or after the retrieval of an inhibitory avoidance (IA) memory elicited with different footshock intensities. In parallel, the same treatment was tested on the reconsolidation of Pavlovian FC. Propranolol showed no effect on the reconsolidation http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Learning & Memory Unpaywall

Limited efficacy of propranolol on the reconsolidation of fear memories

Muravieva, Elizaveta V.; Alberini, Cristina M.
Learning & Memory – Jun 1, 2010
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Unpaywall
ISSN
1072-0502
DOI
10.1101/lm.1794710
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Abstract

Downloaded from learnmem.cshlp.org on October 15, 2021 - Published by Cold Spring Harbor Laboratory Press Research Limited efficacy of propranolol on the reconsolidation of fear memories 1 1,2,3 Elizaveta V. Muravieva and Cristina M. Alberini 1 2 Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA; Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA Previous studies suggested that the b-adrenergic receptor antagonist propranolol might be a novel, potential treatment for post-traumatic stress disorder (PTSD). This hypothesis stemmed mainly from rodent studies showing that propranolol interferes with the reconsolidation of Pavlovian fear conditioning (FC). However, subsequent investigations in humans have produced controversial evidence about the effect of propranolol on fear memories and an effect on PTSD symptomatology has yet to be reported. Thus, it remains to be established whether propranolol interferes with the reconsolidation of fear memories at large. To address this question, we tested the effect of systemic injections of propranolol administered before or after the retrieval of an inhibitory avoidance (IA) memory elicited with different footshock intensities. In parallel, the same treatment was tested on the reconsolidation of Pavlovian FC. Propranolol showed no effect on the reconsolidation

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Learning & Memory – Unpaywall

Published: Jun 1, 2010

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