Nuclear localization signals for four distinct karyopherin-beta nuclear import systems

Soniat M; Chook YM

doi:10.1042/BJ20150368

Transport between the cell nucleus and the cytoplasm

Gorlich

Karyopherins and nuclear import

Chook

Nucleocytoplasmic transport enters the atomic age

Conti

Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle

Weis

SnapShot: nuclear transport

Tran

Structural biology of nucleocytoplasmic transport

Cook

Recognition of nuclear targeting signals by Karyopherin-β proteins

Xu

Nuclear import by karyopherin-βs: recognition and inhibition

Chook

Atomic basis of CRM1-cargo recognition, release and inhibition

Fung

TDP-43 and FUS: a nuclear affair

Dormann

Nuclear transport impairment of amyotrophic lateral sclerosis-linked mutations in FUS/TLS

Ito

Nuclear trafficking in health and disease

Mor

Viral subversion of nucleocytoplasmic trafficking

Yarbrough

Evolution of the karyopherin-β family of nucleocytoplasmic transport factors; ancient origins and continued specialization

O’Reilly

Evolutionary and transcriptional analysis of karyopherin β superfamily proteins

Quan

Atomic resolution structures in nuclear transport

Suel

Structural basis for nuclear import complex dissociation by RanGTP

Lee

Karyopherins: from nuclear-transport mediators to nuclear-function regulators

Mosammaparast

Karyopherin flexibility in nucleocytoplasmic transport

Conti

Transport into and out of the cell nucleus

Gorlich

Mechanisms of receptor-mediated nuclear import and nuclear export

Pemberton

Previously identified protein of uncertain function is karyopherin α and together with karyopherin β docks import substrate at nuclear pore complexes

Moroianu

The essential yeast nucleoporin NUP159 is located on the cytoplasmic side of the nuclear pore complex and serves in karyopherin-mediated binding of transport substrate

Kraemer

A polypeptide domain that specifies migration of nucleoplasmin into the nucleus

Dingwall

Sequence requirements for nuclear location of simian virus 40 large-T antigen

Kalderon

Construction and characterization of an SV40 mutant defective in nuclear transport of T antigen

Lanford

Classical nuclear localization signals: definition, function, and interaction with importin α

Lange

Kap104p imports the PY-NLS-containing transcription factor Tfg2p into the nucleus

Suel

Rules for nuclear localization sequence recognition by karyopherin β2

Lee

Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS)

Zhang

Structural basis for leucine-rich nuclear export signal recognition by CRM1

Dong

NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1

Guttler

Molecular basis for the recognition of a nonclassical nuclear localization signal by importin β

Cingolani

Structure of importin-β bound to the IBB domain of importin-α

Cingolani

Molecular basis for specificity of nuclear import and prediction of nuclear localization

Marfori

Diversification of importin-α isoforms in cellular trafficking and disease states

Pumroy

Transportin-1 and Transportin-2: protein nuclear import and beyond

Twyffels

Reactive oxygen species-mediated DJ-1 monomerization modulates intracellular trafficking involving karyopherin β2

Bjorkblom

The nuclear localization of glycogen synthase kinase 3β is required its putative PY-nuclear localization sequences

Shin

Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kapβ2 in Hedgehog signaling

Shi

A PY-nuclear localization signal is required for nuclear accumulation of HCMV UL79 protein

Wang

Identification of a karyopherin β1/β2 proline-tyrosine nuclear localization signal in huntingtin protein

Desmond

A proline-tyrosine nuclear localization signal (PY-NLS) is required for the nuclear import of fission yeast PAB2, but not of human PABPN1

Mallet

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations

Neumann

Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS

Dormann

A masked PY-NLS in Drosophila TIS11 and its mammalian homolog tristetraprolin

Twyffels

Synchronizing nuclear import of ribosomal proteins with ribosome assembly

Kressler

Transportin acts to regulate mitotic assembly events by target binding rather than Ran sequestration

Bernis

Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and RanGTP

Dishinger

Localization of retinitis pigmentosa 2 to cilia is regulated by Importin β2

Hurd

Crystal structure of human Karyopherin β2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2

Soniat

FUS-NLS/Transportin 1 complex structure provides insights into the nuclear targeting mechanism of FUS and the implications in ALS

Niu

Molecular basis for the recognition of snurportin 1 by importin β

Mitrousis

Importin β recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin α

Lam

The structure of importin-β bound to SREBP-2: nuclear import of a transcription factor

Lee

Quantitative structural analysis of importin-β flexibility: paradigm for solenoid protein structures

Forwood

Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin β

Choi

Importin 13: a novel mediator of nuclear import and export

Mingot

Paired-type homeodomain transcription factors are imported into the nucleus by karyopherin 13

Ploski

Importin 13 mediates nuclear import of histone fold-containing chromatin accessibility complex heterodimers

Walker

Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin β and importin 13

Kahle

Regulation of nuclear import and export of negative cofactor 2

Kahle

Nuclear import mechanism of the EJC component Mago-Y14 revealed by structural studies of importin 13

Bono

Structural basis for cell-cycle-dependent nuclear import mediated by the karyopherin Kap121p

Kobayashi

Structural basis for nuclear import of splicing factors by human Transportin 3

Maertens

A short amino acid sequence able to specify nuclear location

Kalderon

Isolation of a protein that is essential for the first step of nuclear protein import

Gorlich

Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope

Adam

Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins

Radu

The importin β binding domain as a master regulator of nucleocytoplasmic transport

Lott

Structural basis of high-affinity nuclear localization signal interactions with importin-α

Marfori

Identification of cargo proteins specific for importin-β with importin-α applying a stable isotope labeling by amino acids in cell culture (SILAC)-based in vitro transport system

Kimura

Six classes of nuclear localization signals specific to different binding grooves of importin α

Kosugi

Probing the specificity of binding to the major nuclear localization sequence-binding site of importin-α using oriented peptide library screening

Yang

A functional proteomics approach for the detection of nuclear proteins based on derepressed importin α

Blazek

Importin α2-interacting proteins with nuclear roles during mammalian spermatogenesis

Ly-Huynh

Proteomic analysis of importin α-interacting proteins in adult mouse brain

Fukumoto

Towards delineation of a developmental α-importome in the mammalian male germline

Miyamoto

Identification of karyopherin α1 and α7 interacting proteins in porcine tissue

Park

Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin α

Kobe

Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-α

Fontes

Biophysical characterization of interactions involving importin-α during nuclear import

Catimel

Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-α

Fontes

Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-α

Fontes

Phospholipid scramblase 1 contains a nonclassical nuclear localization signal with unique binding site in importin α

Chen

Nup50/Npap60 function in nuclear protein import complex disassembly and importin recycling

Matsuura

Structural basis for the nuclear import of the human androgen receptor

Cutress

The molecular basis for the regulation of the cap-binding complex by the importins

Dias

Novel binding of the mitotic regulator TPX2 (target protein for Xenopus kinesin-like protein 2) to importin-α

Giesecke

A minimal nuclear localization signal (NLS) in human phospholipid scramblase 4 that binds only the minor NLS-binding site of importin α1

Lott

Crystal structure of importin-α bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4

Mynott

Structural basis of importin-α-mediated nuclear transport for Ku70 and Ku80

Takeda

Sensing actin dynamics: structural basis for G-actin-sensitive nuclear import of MAL

Hirano

Structural basis of nuclear import of flap endonuclease 1 (FEN1)

de Barros

Crystal structure of rice importin-α and structural basis of its interaction with plant-specific nuclear localization signals

Chang

Distinctive conformation of minor site-specific nuclear localization signals bound to importin-α

Chang

Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights

Rona

Structural characterisation of the nuclear import receptor importin α in complex with the bipartite NLS of Prp20

Roman

Cytoplasmic TAF2–TAF8–TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules

Trowitzsch

Molecular determinants for nuclear import of influenza A PB2 by importin α isoforms 3 and 7

Pumroy

Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin α

Conti

Structural basis for Nup2p function in cargo release and karyopherin recycling in nuclear import

Matsuura

Modular organization and combinatorial energetics of proline-tyrosine nuclear localization signals

Suel

Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1

Zhang

Conformational heterogeneity of karyopherin β2 is segmental

Cansizoglu

Structure-based design of a pathway-specific nuclear import inhibitor

Cansizoglu

Structural basis for substrate recognition and dissociation by human transportin 1

Imasaki

RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1

Fritz

A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1

Barraud

Transportin regulates nuclear import of CD44

Janiszewska

Redox-dependent control of FOXO/DAF-16 by transportin-1

Putker

Identification and functional implication of nuclear localization signals in the N-terminal domain of JMJD5

Huang

Identification of a nuclear localization signal in the polo box domain of Plk1

Lee

The quantitative assessment of the role played by basic amino acid clusters in the nuclear uptake of human ribosomal protein L7

Tai

Chemokine receptor CCR2 undergoes transportin1-dependent nuclear translocation

Favre

Identification of cargo proteins specific for the nucleocytoplasmic transport carrier transportin by combination of an in vitro transport system and stable isotope labeling by amino acids in cell culture (SILAC)-based quantitative proteomics

Kimura

Importin β, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells

Jakel

Nuclear import of c-Jun is mediated by multiple transport receptors

Waldmann

Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin

Dean

Cell cycle regulated transport controlled by alterations in the nuclear pore complex

Makhnevych

A distinct nuclear import pathway used by ribosomal proteins

Rout

Cloning and characterization of human karyopherin β3

Yaseen

Core histones and linker histones are imported into the nucleus by different pathways

Baake

Multiple pathways contribute to nuclear import of core histones

Muhlhausser

Pathways mediating the nuclear import of histones H3 and H4 in yeast

Mosammaparast

Mutational analysis of H3 and H4 N termini reveals distinct roles in nuclear import

Blackwell

Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121

Kaffman

Nuclear import of Spo12p, a protein essential for meiosis

Chaves

Pse1/Kap121-dependent nuclear localization of the major yeast multidrug resistance (MDR) transcription factor Pdr1

Delahodde

Nuclear import of the yeast AP-1-like transcription factor Yap1p is mediated by transport receptor Pse1p, and this import step is not affected by oxidative stress

Isoyama

Kap121p-mediated nuclear import is required for mating and cellular differentiation in yeast

Leslie

Characterization of karyopherin cargoes reveals unique mechanisms of Kap121p-mediated nuclear import

Leslie

Pse1p mediates the nuclear import of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae

Ueta

Mitosis-specific regulation of nuclear transport by the spindle assembly checkpoint protein Mad1p

Cairo

Karyopherins in nuclear pore biogenesis: a role for Kap121p in the assembly of Nup53p into nuclear pore complexes

Lusk

Transportin-SR, a nuclear import receptor for SR proteins

Kataoka

A human importin-β family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins

Lai

Transportin-SR2 mediates nuclear import of phosphorylated SR proteins

Lai

Phosphorylation-dependent and -independent nuclear import of RS domain-containing splicing factors and regulators

Yun

A conserved Drosophila transportin-serine/arginine-rich (SR) protein permits nuclear import of Drosophila SR protein splicing factors and their antagonist repressor splicing factor 1

Allemand

A novel splicing regulator shares a nuclear import pathway with SR proteins

Lai

Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Npl3p

Senger

Transportin-SR2 imports HIV into the nucleus

Christ

Transportin-SR is required for proper splicing of resistance genes and plant immunity

Xu

Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus

De Iaco

TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm

De Iaco

Transportin regulates major mitotic assembly events: from spindle to nuclear pore assembly

Lau

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Nuclear localization signals for four distinct karyopherin-beta nuclear import systems

Nuclear localization signals for four distinct karyopherin-beta nuclear import systems

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Nuclear localization signals for four distinct karyopherin-beta nuclear import systems

Nuclear localization signals for four distinct karyopherin-beta nuclear import systems

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