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- Publisher
- Oxford University Press
- Copyright
- Copyright © 1991 ASBMR
- ISSN
- 0884-0431
- eISSN
- 1523-4681
- DOI
- 10.1002/jbmr.5650060103
- Publisher site
- See Article on Publisher Site
Abstract
Recombinant human interleukin‐6 (IL‐6) was assessed for its ability to stimulate bone resorption in prelabeled mouse calvariae in vitro. IL‐6 had no effect on bone resorption at concentrations ranging from 300 to 10,000 U/ml (3–1000 pg/ml). Neither the presence of indomethacin nor prolonged incubation periods (96 h) affected this result. IL‐6 did not affect resorption stimulated by human recombinant IL‐1α (rIL‐1α) but inhibited resorption stimulated by parathyroid hormone (PTH) and 1,25‐dihydroxyvitamin D3 [1,25‐(OH)2D3]. rIL‐1α, PTH, and 1,25‐(OH)2D3 induced IL‐6 release by calvariae. We conclude from these studies that IL‐6 does not stimulate bone resorption in neonatal mouse calvariae. However, it may act as a locally produced inhibitor and therefore a paracrine regulator of bone resorption induced by osteotropic hormones. IL‐6 could also function as a long‐range stimulator of systemic reactions and acute‐phase responses to local inflammatory and neoplastic lesions in bone.
Journal
Journal of Bone and Mineral Research – Oxford University Press
Published: Jan 1, 1991