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In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer’s disease

In vivo changes in microglial activation and amyloid deposits in brain regions with... A lack of coupling between microglial activation and amyloid deposits may indicate that Aβ accumulation shown by ( 11 C)PIB is not always the primary cause of microglial activation, but rather the negative correlation present in the PCC suggests that microglia can show higher activation during the production of Aβ in early AD. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Nuclear Medicine and Molecular Imaging Springer Journals

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References (45)

Publisher
Springer Journals
Copyright
Copyright © 2010 by Springer-Verlag
Subject
Medicine & Public Health; Oncology; Cardiology; Orthopedics; Imaging / Radiology; Nuclear Medicine
ISSN
1619-7070
eISSN
1619-7089
DOI
10.1007/s00259-010-1612-0
pmid
20844871
Publisher site
See Article on Publisher Site

Abstract

A lack of coupling between microglial activation and amyloid deposits may indicate that Aβ accumulation shown by ( 11 C)PIB is not always the primary cause of microglial activation, but rather the negative correlation present in the PCC suggests that microglia can show higher activation during the production of Aβ in early AD.

Journal

European Journal of Nuclear Medicine and Molecular ImagingSpringer Journals

Published: Sep 16, 2010

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