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Disturbed surround inhibition in focal hand dystonia

Disturbed surround inhibition in focal hand dystonia Disturbances in surround inhibition could account for various movement disorders. Here we test the functional operation of surround inhibition in focal hand dystonia. Transcranial magnetic stimulation was set to be triggered by self‐initiated voluntary flexion of the index finger. During this movement, motor‐evoked potential amplitudes from the little finger muscle were significantly suppressed in healthy subjects but enhanced in dystonia patients. This result supports the idea that disturbed surround inhibition is a principal pathophysiological mechanism of dystonia. Ann Neurol 2004;56:595–599 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Neurology Wiley

Disturbed surround inhibition in focal hand dystonia

Annals of Neurology , Volume 56 (4) – Oct 1, 2004

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References (17)

Publisher
Wiley
Copyright
Copyright © 2004 American Neurological Association
ISSN
0364-5134
eISSN
1531-8249
DOI
10.1002/ana.20270
pmid
15455393
Publisher site
See Article on Publisher Site

Abstract

Disturbances in surround inhibition could account for various movement disorders. Here we test the functional operation of surround inhibition in focal hand dystonia. Transcranial magnetic stimulation was set to be triggered by self‐initiated voluntary flexion of the index finger. During this movement, motor‐evoked potential amplitudes from the little finger muscle were significantly suppressed in healthy subjects but enhanced in dystonia patients. This result supports the idea that disturbed surround inhibition is a principal pathophysiological mechanism of dystonia. Ann Neurol 2004;56:595–599

Journal

Annals of NeurologyWiley

Published: Oct 1, 2004

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