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EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM https://doi.org/10.1080/17446651.2024.2320639 EDITORIAL The diagnostic challenges of functioning neuroendocrine tumors: balancing accuracy, availability, and personalized care Sara Massironi Division of Gastroenterology, Fondazione IRCCS San Gerardo dei Tintori, University of Milano-Bicocca, School of Medicine, Monza, Italy ARTICLE HISTORY Received 12 August 2023; Accepted 15 February 2024 KEYWORDS Circulating markers; functioning neuroendocrine neoplasms; gastro-entero-pancreatic neuroendocrine tumors; neuroendocrine; specific markers Neuroendocrine neoplasms (NENs) represent a complex and assessment of circulating markers be performed only in spe- multifaceted group of tumors, drawing attention to their intri- cific circumstances [9,10], necessitating a deep understanding guing characteristics and clinical implications. Their incidence of the different clinical contexts that warrant marker assess- has increased worldwide in recent decades [1,2]. These neo- ment. Whether diagnosing functioning NENs or determining plasms exhibit an exceptional ability to intertwine both endo- the course of a treatment plan, recognizing these circum- crine and oncological aspects, posing distinctive challenges to stances becomes the cornerstone for accurate decision- physicians seeking to unravel their complexities. Indeed, NENs making. represent heterogeneous tumors, with different biological This feature introduces notable complexity, demanding an aggressiveness and encompass a diverse spectrum of tumors intricate grasp of both endocrinology and oncology. This con- that
Expert Review of Endocrinology & Metabolism – Taylor & Francis
Published: Mar 3, 2024
Keywords: Circulating markers; functioning neuroendocrine neoplasms; gastro-entero-pancreatic neuroendocrine tumors; neuroendocrine; specific markers
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