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- Publisher
- Springer Journals
- Copyright
- Copyright
- Subject
- Medicine & Public Health; Medicine/Public Health, general; Pediatrics; Pediatric Surgery
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- DOI
- 10.1203/00006450-200207000-00005
- Publisher site
- See Article on Publisher Site
Abstract
Human naive CD4+ T helper (Th) and CD8+ cytotoxic (Tc) T cells, which only produce IL-2, may differentiate into Th1/Tc1- or Th2/Tc2-like lymphocytes, characterized by their cytokine production profile. 1α,25-dihydroxyvitamin D3 (1α, 25(OH)2D3) has been reported to inhibit Th1/Tc1-related, but increase Th2/Tc2-associated cytokines in T cells from adults. In industrialized countries, vitamin D supplementation for prevention of rickets is initiated within the first days of life and continued throughout the entire first year. Epidemiologic studies suggest an association of vitamin D exposure in newborns with the incidence of allergic diseases in later life. This study addresses the effects of 1α, 25(OH)2D3 on Th1/Tc1 versus Th2/Tc2 differentiation in long term cell cultures of (naive) cord blood T lymphocytes. Our results show that in CD4+ as well as CD8+ cord blood cells, 1α, 25(OH)2D3 inhibits not only IL-12-generated IFN-γ production, but also suppresses IL-4 and IL-13 expression induced by IL-4. Thus, in cord blood 1α, 25(OH)2D3 induces a T cell population without predominance of Th2 related cytokines.
Journal
Pediatric Research – Springer Journals
Published: Jul 1, 2002