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Vascular Protection Superoxide Dismutase Isoforms in the Vessel Wall

Vascular Protection Superoxide Dismutase Isoforms in the Vessel Wall ATVB In Focus Endothelium: Signaling, Oxidative Stress, and Gene Expression Series Editor: Frank M. Faraci Previous Brief Review in this Series:  Wolfrum S. Jensen KS, Liao JK. Endothelium dependent effects of statins. 2003;23:729 –736.  Frank PG, Woodman SE, Park DS, Lisanti MP. Caveolin, caveolae, and endothelial cell function. 2003;23:1161–1168.  Katusic ZS, Caplice NM, Nath KA. Nitric oxide synthase gene transfer as a tool to study biology of endothelial cells. 2003;23:1990 –1995. Vascular Protection Superoxide Dismutase Isoforms in the Vessel Wall Frank M. Faraci, Sean P. Didion Abstract—Blood vessels express 3 isoforms of superoxide dismutase (SOD): cytosolic or copper-zinc SOD (CuZn-SOD), manganese SOD (Mn-SOD) localized in mitochondria, and an extracellular form of CuZn-SOD (EC-SOD). Because there are no selective pharmacological inhibitors of individual SOD isoforms, the functional importance of the different SODs has been difficult to define. Recent molecular approaches, primarily the use of genetically-altered mice and viral-mediated gene transfer, have allowed investigators to begin to define the role of specific SOD isoforms in vascular biology. This review will focus mainly on the role of individual SODs in relation to endothelium under normal conditions and in disease states. This area is important because reactive oxygen species and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png "Arteriosclerosis, Thrombosis, and Vascular Biology" Wolters Kluwer Health

Vascular Protection Superoxide Dismutase Isoforms in the Vessel Wall

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ISSN
0002-936X
eISSN
1524-4636
DOI
10.1161/01.ATV.0000133604.20182.cf
pmid
15166009
Publisher site
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Abstract

ATVB In Focus Endothelium: Signaling, Oxidative Stress, and Gene Expression Series Editor: Frank M. Faraci Previous Brief Review in this Series:  Wolfrum S. Jensen KS, Liao JK. Endothelium dependent effects of statins. 2003;23:729 –736.  Frank PG, Woodman SE, Park DS, Lisanti MP. Caveolin, caveolae, and endothelial cell function. 2003;23:1161–1168.  Katusic ZS, Caplice NM, Nath KA. Nitric oxide synthase gene transfer as a tool to study biology of endothelial cells. 2003;23:1990 –1995. Vascular Protection Superoxide Dismutase Isoforms in the Vessel Wall Frank M. Faraci, Sean P. Didion Abstract—Blood vessels express 3 isoforms of superoxide dismutase (SOD): cytosolic or copper-zinc SOD (CuZn-SOD), manganese SOD (Mn-SOD) localized in mitochondria, and an extracellular form of CuZn-SOD (EC-SOD). Because there are no selective pharmacological inhibitors of individual SOD isoforms, the functional importance of the different SODs has been difficult to define. Recent molecular approaches, primarily the use of genetically-altered mice and viral-mediated gene transfer, have allowed investigators to begin to define the role of specific SOD isoforms in vascular biology. This review will focus mainly on the role of individual SODs in relation to endothelium under normal conditions and in disease states. This area is important because reactive oxygen species and

Journal

"Arteriosclerosis, Thrombosis, and Vascular Biology" – Wolters Kluwer Health

Published: Aug 1, 2004

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