Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/sheet-breaker-peptides-inhibit-fibrillogenesis-in-a-rat-brain-model-of-0X0RFVJsGn
References (31)
-
B. Yankner (1996)
Mechanisms of Neuronal Degeneration in Alzheimer's DiseaseNeuron, 16
-
P. Arriagada, J. Growdon, E. Hedley‐Whyte, B. Hyman (1992)
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's diseaseNeurology, 42
-
WP Esler (1997)
Aβ deposition inhibitor screen using synthetic amyloidNature Biotechnol., 15
-
E.M Sigurdsson, J.M Lee, Xin-W. Dong, M. Hejna, S. Lorens (1997)
Bilateral Injections of Amyloid-β 25-35 into the Amygdala of Young Fischer Rats: Behavioral, Neurochemical, and Time Dependent Histopathological EffectsNeurobiology of Aging, 18
-
C. Soto, E. Castaño, B. Frangione, N. Inestrosa (1995)
The -Helical to -Strand Transition in the Amino-terminal Fragment of the Amyloid -Peptide Modulates Amyloid Formation *The Journal of Biological Chemistry, 270
-
D. Games, David Adams, Ree Alessandrini, R. Barbour, Patricia Borthelette, C. Blackwell, Tony Carr, J. Clemens, T. Donaldson, F. Gillespie, T. Guido, S. Hagopian, K. Johnson-wood, K. Khan, Mike Lee, P. Leibowitz, I. Lieberburg, S. Little, E. Masliah, L. McConlogue, M. Montoya-Zavala, L. Mucke, L. Paganini, E. Penniman, M. Power, D. Schenk, P. Seubert, B. Snyder, F. Soriano, H. Tan, J. Vitale, S. Wadsworth, B. Wolozin, Jun Zhao (1995)
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor proteinNature, 373
-
E. Sigurdsson, S. Lorens, M. Hejna, X. Dong, John Lee (1996)
Local and distant histopathological effects of unilateral amyloid-β 25–35 injections into the amygdala of young F344 ratsNeurobiology of Aging, 17
-
Jonathan Lee, E. Stimson, Ghilardi, P. Mantyh, Y.-a. Lu, Arthur Felix, William Llanos, A. Behbin, M. Cummings, M. VanCriekinge (1995)
1H NMR of A beta amyloid peptide congeners in water solution. Conformational changes correlate with plaque competence.Biochemistry, 34 15
-
G. Glenner (1980)
Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts).The New England journal of medicine, 302 23
-
E. Coligan (1991)
Current protocols in immunology -
P. Thomas, B. Qu, P. Pedersen (1995)
Defective protein folding as a basis of human disease.Trends in biochemical sciences, 20 11
-
GG Glenner (1980)
Amyloid deposits and amyloidosis. The β-fibrillosesN. Engl. J. Med., 302
-
C Soto, EM Castaño, B Frangione, NC Inestrosa (1995)
The alpha-helical to beta-strand transition in the amino-terminal fragment of the amyloid beta-peptide modulates amyloid formationJ. Biol. Chem., 270
-
C. Hilbich, B. Kisters-Woike, J. Reed, C. Masters, K. Beyreuther (1992)
Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides.Journal of molecular biology, 228 2
-
Thomas Wisniewski, J. Ghiso, B. Frangione (1994)
Alzheimer's disease and soluble AβNeurobiology of Aging, 15
-
A. Jiménez‐Huete, P. Alfonso, C. Jara, J. Albar, A. Rábano, J. Ghiso, B. Frangione, E. Méndez (1998)
Antibodies directed to the carboxyl terminus of amyloid β-peptide recognize sequence epitopes and distinct immunoreactive deposits in Alzheimer's disease brain, 1
-
A. Lorenzo, B. Yankner (1994)
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.Proceedings of the National Academy of Sciences of the United States of America, 91 25
-
P. Chou, G. Fasman (1978)
Empirical predictions of protein conformation.Annual review of biochemistry, 47
-
S. Wood, R. Wetzel, J. Martín, M. Hurle (1995)
Prolines and amyloidogenicity in fragments of the Alzheimer's peptide beta/A4.Biochemistry, 34 3
-
C. Soto, M. Brañes, J. Alvarez, N. Inestrosa (1994)
Structural Determinants of the Alzheimer's Amyloid β‐PeptideJournal of Neurochemistry, 63
-
Claudio Soto, M. Kindy, Marc Baumann, Blas Frangione (1996)
Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation.Biochemical and biophysical research communications, 226 3
-
J. Kelly (1996)
Alternative conformations of amyloidogenic proteins govern their behavior.Current opinion in structural biology, 6 1
-
C. Soto, E. Castaño, F. Prelli, R. Kumar, M. Baumann (1995)
Apolipoprotein E increases the fibrillogenic potential of synthetic peptides derived from Alzheimer's, Gelsolin and AA amyloidsFEBS Letters, 371
-
L. Simmons, P. May, K. Tomaselli, R. Rydel, Kimberly Fuson, E. Brigham, S. Wright, I. Lieberburg, G. Becker, D. Brems (1994)
Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro.Molecular pharmacology, 45 3
-
K. Hsiao, P. Chapman, S. Nilsen, C. Eckman, Y. Harigaya, S. Younkin, Fusheng Yang, G. Cole (1996)
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic MiceScience, 274
-
L. Holcomb, M. Gordon, E. McGowan, Xin Yu, S. Benkovic, P. Jantzen, K. Wright, Irene Saad, R. Mueller, D. Morgan, S. Sanders, C. Zehr, Kassandra O'Campo, J. Hardy, C. Prada, C. Eckman, S. Younkin, K. Hsiao, K. Duff (1998)
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenesNature Medicine, 4
-
Stephen Wood, B. Maleeff, Timothy Hart, Ronald Wetzel (1996)
Physical, morphological and functional differences between ph 5.8 and 7.4 aggregates of the Alzheimer's amyloid peptide Abeta.Journal of molecular biology, 256 5
-
C. Pike, D. Burdick, A. Walencewicz, C. Glabe, C. Cotman (1993)
Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state, 13
-
A. Lorenzo, B. Razzaboni, G. Weir, B. Yankner (1994)
Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitusNature, 368
-
G. Forloni, N. Angeretti, R. Chiesa, E. Monzani, M. Salmona, O. Bugiani, F. Tagliavini (1993)
Neurotoxicity of a prion protein fragmentNature, 362
-
G. Janossy, M. Greaves, M. Doenhoff, J. Šnajdr (1973)
Lymphocyte activation. V. Quantitation of the proliferative responses to mitogens using defined T and B cell populations.Clinical and experimental immunology, 14 4
- Publisher
- Springer Journals
- Copyright
- Copyright © 1998 by Nature Publishing Group
- Subject
- Biomedicine; Biomedicine, general; Cancer Research; Metabolic Diseases; Infectious Diseases; Molecular Medicine; Neurosciences
- ISSN
- 1078-8956
- eISSN
- 1546-170X
- DOI
- 10.1038/nm0798-822
- Publisher site
- See Article on Publisher Site
Abstract
Inhibition of cerebral amyloid β-protein deposition seems to be an important target for Alzheimer's disease therapy. Amyloidogenesis could be inhibited by short synthetic peptides designed as β-sheet breakers. Here we demonstrate a 5-residue peptide that inhibits amyloid βprotein fibrillogenesis, disassembles preformed fibrils in vitro and prevents neuronal death induced by fibrils in cell culture. In addition, the β-sheet breaker peptide significantly reduces amyloid βprotein deposition in vivo and completely blocks the formation of amyloid fibrils in a rat brain model of amyloidosis. These findings may provide the basis for a new therapeutic approach to prevent amyloidosis in Alzheimer's disease.
Journal
Nature Medicine – Springer Journals
Published: Jul 1, 1998