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The effects of oestrogen and progesterone on insulin sensitivity in female rats

The effects of oestrogen and progesterone on insulin sensitivity in female rats The effects of 17‐β‐oestradiol (E2) and progesterone (P) on insulin sensitivity were determined in oophorectomized (OVX) rats by the euglycaemic hyperinsulinaemic clamp technique combined with measurements of insulin‐stimulated 2‐deoxy‐D‐glucose (2‐DOG) transport and glycogen synthesis in white and red parts of the gastrocnemius, the extensor digitorum longus and soleus muscles as well as in the liver (only glycogen synthesis). OVX was followed by insulin resistance in the clamp measurements. This was paralleled by a decreased insulin‐stimulated content of 2‐DOG in muscles, an index of glucose transport. Glycogen synthesis in muscle was also decreased, although to less extent. E2, alone or in combination with P, restored this to values of intact controls, while P alone was followed by insulin resistance. Liver glycogen synthesis was also decreased by OVX but this required combination of E2 and P to be fully restored. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Physiologica Wiley

The effects of oestrogen and progesterone on insulin sensitivity in female rats

KUMAGAI, S.; HOLMÄNG, A.; BJÖRNTORP, P.
Acta Physiologica , Volume 149 (1) – Sep 1, 1993
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References (19)

Publisher
Wiley
Copyright
Copyright © 1993 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1748-1708
eISSN
1748-1716
DOI
10.1111/j.1748-1716.1993.tb09596.x
pmid
8237427
Publisher site
See Article on Publisher Site

Abstract

The effects of 17‐β‐oestradiol (E2) and progesterone (P) on insulin sensitivity were determined in oophorectomized (OVX) rats by the euglycaemic hyperinsulinaemic clamp technique combined with measurements of insulin‐stimulated 2‐deoxy‐D‐glucose (2‐DOG) transport and glycogen synthesis in white and red parts of the gastrocnemius, the extensor digitorum longus and soleus muscles as well as in the liver (only glycogen synthesis). OVX was followed by insulin resistance in the clamp measurements. This was paralleled by a decreased insulin‐stimulated content of 2‐DOG in muscles, an index of glucose transport. Glycogen synthesis in muscle was also decreased, although to less extent. E2, alone or in combination with P, restored this to values of intact controls, while P alone was followed by insulin resistance. Liver glycogen synthesis was also decreased by OVX but this required combination of E2 and P to be fully restored.

Journal

Acta Physiologica – Wiley

Published: Sep 1, 1993

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