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- Publisher
- Wiley
- Copyright
- © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
- ISSN
- 0736-0266
- eISSN
- 1554-527X
- DOI
- 10.1002/jor.23258
- pmid
- 27061844
- Publisher site
- See Article on Publisher Site
Abstract
Immune Modulation With Primed Mesenchymal Stem Cells Delivered Via Biodegradable Scaffold to Repair an Achilles Tendon Segmental Defect 1 2 3 3 3 Erdem Aktas, Connie S. Chamberlain, Erin E. Saether, Sarah E. Duenwald-Kuehl, Jaclyn Kondratko-Mittnacht, 3 3 2 2,3 2,3 Michael Stitgen, Jae Sung Lee, Anna E. Clements, William L. Murphy, Ray Vanderby 1 2 Department of Orthopedics, Ankara Oncology Research and Training Hospital, Ankara, Turkey, Department of Orthopedics and Rehabilitation, University of Wisconsin, Madison, Wisconsin 53705, Department of Biomedical Engineering, University of Wisconsin, Madison, Wisconsin Received 25 November 2015; accepted 4 April 2016 Published online 25 April 2016 in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/jor.23258 ABSTRACT: Tendon healing is a complex coordinated series of events resulting in protracted recovery, limited regeneration, and scar formation. Mesenchymal stem cell (MSC) therapy has shown promise as a new technology to enhance soft tissue and bone healing. A challenge with MSC therapy involves the ability to consistently control the inflammatory response and subsequent healing. Previous studies suggest that preconditioning MSCs with inflammatory cytokines, such as IFN-g, TNF-a, and IL-1b may accelerate cutaneous wound closure. The objective of this study was to therefore elucidate these effects in tendon. That is, the in
Journal
Journal of Orthopaedic Research – Wiley
Published: Feb 1, 2017
Keywords: ; ; ; ;