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Age Differences in Short-Term Memory and Cell Loss in the Cortex of the Rat

Age Differences in Short-Term Memory and Cell Loss in the Cortex of the Rat Studies with human and animal subjects have indicated age declines in short-term memory and cell loss in the cortex. Cell loss has been estimated by descriptive nonautomated methods. Declines in short-term memory may be related to reduced learning, motivation, motor capacity, or some combination of these factors. Passive-avoidance tests of memory minimize these factors. Direct correlational studies on learning and memory in relation to cell loss in the same subject are not feasible in man and they have not been reported previously in animals. The aims of this study were to examine age differences in learning and short-term passive-avoidance memory in relation to cell packing density in the visual cortex of the Fisher 344 rat. Cell counts were made with a computer-guided, automated, image-analyzing system (TAS, Leitz). The following observations were made: http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Gerontology Karger

Age Differences in Short-Term Memory and Cell Loss in the Cortex of the Rat

Ordy, Mark; Brizzee, Kenneth.R.; Kaack, Bernice; Hansche, Jay
Gerontology , Volume 24 (4): 10 – Jan 1, 1978
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Publisher
Karger
Copyright
© 1978 S. Karger AG, Basel
ISSN
0304-324X
eISSN
1423-0003
DOI
10.1159/000212260
Publisher site
See Article on Publisher Site

Abstract

Studies with human and animal subjects have indicated age declines in short-term memory and cell loss in the cortex. Cell loss has been estimated by descriptive nonautomated methods. Declines in short-term memory may be related to reduced learning, motivation, motor capacity, or some combination of these factors. Passive-avoidance tests of memory minimize these factors. Direct correlational studies on learning and memory in relation to cell loss in the same subject are not feasible in man and they have not been reported previously in animals. The aims of this study were to examine age differences in learning and short-term passive-avoidance memory in relation to cell packing density in the visual cortex of the Fisher 344 rat. Cell counts were made with a computer-guided, automated, image-analyzing system (TAS, Leitz). The following observations were made:

Journal

Gerontology – Karger

Published: Jan 1, 1978

Keywords: Cell loss; Cerebral cortex; Learning; Old rats; Short-term memory

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