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Estrogens and prostatic disease

Estrogens and prostatic disease INTRODUCTION The leadership, research endeavors, and total commitment of Gerry Murphy to the greater understanding of prostate cancer and its conquest have done so much to bring a multidisciplinary approach to the concept “from the laboratory bench to the bedside.” Such leadership provides inspiration to lesser mortals, and the contributors to this review of the topics discussed at a recent International Prostate Health Council (IPHC) workshop in Antwerp, which Gerry Murphy was to co-chair, consider themselves privileged to have it included in this memorial issue of The Prostate. In 1962, Huggins [1] highlighted certain issues that offered a challenge to researchers at that time (Fig. 1), and it must be said that such problems still exercise the minds of today’s investigators. Huggins and Murphy both empathized well with the concept of the commonality in cancers of the breast and prostate, both steroid-sensitive and possibly related genetically, in that there is, for example, a high frequency of prostatic cancer in relatives of women with breast cancer and a similar geographical distribution around the world (Fig. 2). This decreased prevalence of these endocrine cancers in the people of the East, the differences in incidence of prostate cancer between AfricanAmerican and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Prostate Wiley

Estrogens and prostatic disease

Griffiths, Keith; ,
The Prostate , Volume 45 (2) – Jan 1, 2000
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References (78)

Publisher
Wiley
Copyright
Copyright © 2000 Wiley Subscription Services
ISSN
0270-4137
eISSN
1097-0045
DOI
10.1002/1097-0045(20001001)45:2<87::AID-PROS2>3.0.CO;2-G
Publisher site
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Abstract

INTRODUCTION The leadership, research endeavors, and total commitment of Gerry Murphy to the greater understanding of prostate cancer and its conquest have done so much to bring a multidisciplinary approach to the concept “from the laboratory bench to the bedside.” Such leadership provides inspiration to lesser mortals, and the contributors to this review of the topics discussed at a recent International Prostate Health Council (IPHC) workshop in Antwerp, which Gerry Murphy was to co-chair, consider themselves privileged to have it included in this memorial issue of The Prostate. In 1962, Huggins [1] highlighted certain issues that offered a challenge to researchers at that time (Fig. 1), and it must be said that such problems still exercise the minds of today’s investigators. Huggins and Murphy both empathized well with the concept of the commonality in cancers of the breast and prostate, both steroid-sensitive and possibly related genetically, in that there is, for example, a high frequency of prostatic cancer in relatives of women with breast cancer and a similar geographical distribution around the world (Fig. 2). This decreased prevalence of these endocrine cancers in the people of the East, the differences in incidence of prostate cancer between AfricanAmerican and

Journal

The Prostate – Wiley

Published: Jan 1, 2000

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