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Abnormal Cardiac and Skeletal Muscle Energy Metabolism in Patients With Type 2 Diabetes

Abnormal Cardiac and Skeletal Muscle Energy Metabolism in Patients With Type 2 Diabetes Abnormal Cardiac and Skeletal Muscle Energy Metabolism in Patients With Type 2 Diabetes Michaela Scheuermann-Freestone, MD; Per L. Madsen, MD; David Manners, DPhil; Andrew M. Blamire, PhD; Robin E. Buckingham, PhD; Peter Styles, DPhil; George K. Radda, DPhil; Stefan Neubauer, MD; Kieran Clarke, PhD Background—It is well known that patients with type 2 diabetes have increased risk of cardiovascular disease, but it is not known whether they have underlying abnormalities in cardiac or skeletal muscle high-energy phosphate metabolism. Methods and Results—We studied 21 patients with type 2 diabetes with no evidence of coronary artery disease or impaired cardiac function, as determined by echocardiography, and 15 age-, sex-, and body mass index–matched control subjects. Cardiac high-energy phosphate metabolites were measured at rest using P nuclear magnetic resonance spectroscopy (MRS). Skeletal muscle high-energy phosphate metabolites, intracellular pH, and oxygenation were measured using P MRS and near infrared spectrophotometry, respectively, before, during, and after exercise. Although their cardiac morphology, mass, and function appeared to be normal, the patients with diabetes had significantly lower phospho- creatine (PCr)/ATP ratios, at 1.500.11, than the healthy volunteers, at 2.300.12. The cardiac PCr/ATP ratios correlated negatively with the fasting plasma free fatty acid concentrations. Although skeletal muscle http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation Wolters Kluwer Health

Abnormal Cardiac and Skeletal Muscle Energy Metabolism in Patients With Type 2 Diabetes

Clarke, Kieran
Circulation , Volume 107 (24) – Jun 1, 2003
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Copyright
© 2003 American Heart Association, Inc.
ISSN
0009-7322
eISSN
1524-4539
DOI
10.1161/01.CIR.0000072789.89096.10
pmid
12810608
Publisher site
See Article on Publisher Site

Abstract

Abnormal Cardiac and Skeletal Muscle Energy Metabolism in Patients With Type 2 Diabetes Michaela Scheuermann-Freestone, MD; Per L. Madsen, MD; David Manners, DPhil; Andrew M. Blamire, PhD; Robin E. Buckingham, PhD; Peter Styles, DPhil; George K. Radda, DPhil; Stefan Neubauer, MD; Kieran Clarke, PhD Background—It is well known that patients with type 2 diabetes have increased risk of cardiovascular disease, but it is not known whether they have underlying abnormalities in cardiac or skeletal muscle high-energy phosphate metabolism. Methods and Results—We studied 21 patients with type 2 diabetes with no evidence of coronary artery disease or impaired cardiac function, as determined by echocardiography, and 15 age-, sex-, and body mass index–matched control subjects. Cardiac high-energy phosphate metabolites were measured at rest using P nuclear magnetic resonance spectroscopy (MRS). Skeletal muscle high-energy phosphate metabolites, intracellular pH, and oxygenation were measured using P MRS and near infrared spectrophotometry, respectively, before, during, and after exercise. Although their cardiac morphology, mass, and function appeared to be normal, the patients with diabetes had significantly lower phospho- creatine (PCr)/ATP ratios, at 1.500.11, than the healthy volunteers, at 2.300.12. The cardiac PCr/ATP ratios correlated negatively with the fasting plasma free fatty acid concentrations. Although skeletal muscle

Journal

Circulation – Wolters Kluwer Health

Published: Jun 1, 2003

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