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An Ultrastructural Study of Chronic Sodium Cyanate-Induced Neuropathy

An Ultrastructural Study of Chronic Sodium Cyanate-Induced Neuropathy Abstract Fifteen rats were given a sodium cyanate-rich diet for 18 months and at the end of that period, all of them had developed motor weakness and were perfused for ultrastructural study A peripheral neuropathy involving mostly the roots and sciatic nerves was found and the main ultrastructural lesion was vacuolization of myelin. There was marked distension of the myelin sheaths and phagocytosis of myelin. Axoplasmic changes were minimal and consisted of accumulation of glycogen within vacuoles. Invaginations of adaxonal Schwann cell membranes and axolemma forming loops and separate chambers were also present. There was active participation of macrophages in the splitting of myelin as well as in phagocytosis of myelin remnants. There was evidence of remyelination with the toxic damage. We concluded that cyanate induced neuropathy is due mostly to a myelinotoxic effect of the drug, although parallel but less intense axonal damage cannot be excluded. This content is only available as a PDF. Author notes From Department of Medicine and Pathology, Albert Einstein College of Medicine, Bronx, New York 10461 and The Rockefeller University, New York, New York 10021. Copyright © 1977 by The Association of the Journal of Neuropathology and Experimental Neurology Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neuropathology & Experimental Neurology Oxford University Press

An Ultrastructural Study of Chronic Sodium Cyanate-Induced Neuropathy

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Publisher
Oxford University Press
Copyright
Copyright © 1977 by The Association of the Journal of Neuropathology and Experimental Neurology Inc.
ISSN
0022-3069
eISSN
1554-6578
DOI
10.1097/00005072-197703000-00009
Publisher site
See Article on Publisher Site

Abstract

Abstract Fifteen rats were given a sodium cyanate-rich diet for 18 months and at the end of that period, all of them had developed motor weakness and were perfused for ultrastructural study A peripheral neuropathy involving mostly the roots and sciatic nerves was found and the main ultrastructural lesion was vacuolization of myelin. There was marked distension of the myelin sheaths and phagocytosis of myelin. Axoplasmic changes were minimal and consisted of accumulation of glycogen within vacuoles. Invaginations of adaxonal Schwann cell membranes and axolemma forming loops and separate chambers were also present. There was active participation of macrophages in the splitting of myelin as well as in phagocytosis of myelin remnants. There was evidence of remyelination with the toxic damage. We concluded that cyanate induced neuropathy is due mostly to a myelinotoxic effect of the drug, although parallel but less intense axonal damage cannot be excluded. This content is only available as a PDF. Author notes From Department of Medicine and Pathology, Albert Einstein College of Medicine, Bronx, New York 10461 and The Rockefeller University, New York, New York 10021. Copyright © 1977 by The Association of the Journal of Neuropathology and Experimental Neurology Inc.

Journal

Journal of Neuropathology & Experimental Neurology – Oxford University Press

Published: Mar 1, 1977

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