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- Publisher
- Oxford University Press
- Copyright
- © Published by Oxford University Press.
- Subject
- Major Articles
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- DOI
- 10.1086/340412
- pmid
- 12023761
- Publisher site
- See Article on Publisher Site
Abstract
Clearance of apoptotic cells increases macrophage secretion of antiinflammatory mediators and might modulate viral replication in human immunodeficiency virus (HIV) type 1-infected macrophages. To study this, primary macrophages were infected with HIV-1 and exposed to apoptotic cells. It was found that phagocytosis of apoptotic cells potently enhanced HIV-1 growth. The peptide Arg-Gly-Asp-Ser, which binds to integrin receptors, inhibited the uptake of apoptotic cells and the subsequent enhancement of HIV-1 replication. Viral replication was preceded by increased secretion of transforming growth factor (TGF)-β1 and partially reverted by anti-TGF-β1 antibodies. Moreover, anti-TGF-β1 antibodies inhibited HIV-1 replication in macrophages not exposed to apoptotic cells. A positive correlation was observed between TGFb1 production and HIV-1 growth, and the addition of TGF-β1 amplified HIV-1 replication in macrophages from low TGF-β1 producers. The findings suggest that TGF-β1 favors HIV-1 replication in macrophages and that the clearance of apoptotic cells by HIV-1-infected macrophages contributes to persistent viremia in patients infected with HIV-1.
Journal
Journal of Infectious Diseases – Oxford University Press
Published: Jun 1, 2002