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/lp/taylor-francis/mechanistically-linking-age-related-diseases-and-dietary-carbohydrate-00VRenMPTm
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- Publisher
- Taylor & Francis
- Copyright
- Copyright © 2012 Landes Bioscience
- ISSN
- 1554-8635
- eISSN
- 1554-8627
- DOI
- 10.4161/auto.21150
- pmid
- 22906982
- Publisher site
- See Article on Publisher Site
Abstract
Epidemiological data indicate that consuming diets that deliver sugar to the blood rapidly (called high glycemic index, GI) is associated with enhanced risk for age-related diseases such as cardiovascular disease, type 2 diabetes, cataract and age-related macular degeneration (AMD). These debilities are associated with accumulation of toxic protein aggregates as observed in other protein precipitation or amyloid diseases including Alzheimer, Parkinson and Huntington diseases and encephalopathies. Barriers to recommending lower-GI diets to promote health include the absence of established intracellular biochemical mechanisms that link high-GI diets to compromised homeostasis. The data herein corroborate the epidemiological findings and provide platforms to elucidate additional mechanistic aspects of salutary effects of consuming diets of different GIs. They are also useful for testing drugs, including autophagy enhancers, glycemia regulators, or nutraceuticals, which can be exploited to extend health.
Journal
Autophagy – Taylor & Francis
Published: Sep 14, 2012
Keywords: aging; autophagy; carbohydrate; diet; disease; glycation; glycemic index; lysosome; proteolysis; sugar; ubiquitin