Cândido, Júlia Sosa Antunes; Brant, Luisa Campos; Camelo, Lidyane Valle; Pedrosa, Jesiana Ferreira; Giatti, Luana; Mill, José Geraldo; Ribeiro, Antonio Luiz Pinho; Barreto, Sandhi Maria; Scholze, Alexandra
doi: 10.1155/ijne/9818803pmid: 41215959
Satonaka, Hiroshi; Yokoyama, Shohei; Ishimitsu, Akira; Takahashi, Chisato; Rai, Tatemitsu; Nagata, Daisuke; Ishimitsu, Toshihiko; Tojo, Akihiro; Kershaw, David
doi: 10.1155/ijne/5598055pmid: 40575587
Eucommia ulmoides (Tochu) has been shown to possess a variety of beneficial effects on profiles affecting the onset of lifestyle‐ or aging‐related diseases, such as hypertension, diabetes, dyslipidemia, or obesity. This exploratory single‐arm clinical study was conducted on a total of 17 participants including those with mild chronic kidney disease (CKD) (n = 9), who were administered a tablet product containing Tochu leaf extract for a short period (median: 33 days), to investigate its effects on blood pressure or related clinical markers. Mean systolic blood pressure (SBP) of all the participants significantly decreased from 128.3 ± 12.3 mmHg at the start to 123.8 ± 10.2 mmHg at the end of the administration (p < 0.05). Analysis of CKD patients alone, however, revealed that SBP, to a greater extent, decreased from 130.7 ± 12.9 mmHg to 121.2 ± 10.7 mmHg (p < 0.01), while the change in non‐CKD patients was not significant. Furthermore, SBP decrease in CKD patients with hypertension (n = 7) alone was also significant and comparable. Mean blood oxidative stress index of all participants was decreased from 300.2 ± 76.7 U.CARR to 285.9 ± 63.0 U.CARR (p < 0.05), while median atrial natriuretic peptide (ANP) of all the participants was increased from 8.1 (5.0–9.6) pg/mL to 8.8 (5.8–12.1) pg/mL (p < 0.05). Our findings suggested that Tochu‐derived components may have potential therapeutic benefit at earlier stages in CKD, which could fill the gaps in currently underserved opportunities for prevention or intervention.
Tiwari, Ankit; M., Niranjan; Kalidindi, Karthik; Herur, Siddharth; Dudani, Anshul; Bukka, Vijay Chander; Taduri, Gangadhar; Guditi, Swarnalatha; Mattoo, Tej
doi: 10.1155/ijne/5375585pmid: 41142174
Msilanga, Daniel; Nkwera, Upendo; Punatar, Priyank; Mngumi, Jonathan; Msangi, Elizabeth; Valentine, Gudila; Mushi, Happiness; Shoo, Jacqueline; Agarwal, Anil K.
doi: 10.1155/ijne/9980961pmid: 41221219
Alza-Arcila, Lyzinhawer; Echeverri-Fernández, Esteban; Restrepo-Escobar, Mauricio; Calderón, Ligia Lorena; Ustáriz, José Manuel; Arias-Restrepo, Luis Fernando; Rodelo-Ceballos, Joaquín Roberto; Kershaw, David
doi: 10.1155/ijne/6974280pmid: 40224579
Introduction: The Oxford/MEST‐C classification is a histopathological scoring system for patients with IgA nephropathy (IgAN) that has demonstrated prognostic utility. The aim of this study was to evaluate the prognostic utility of the combination of clinical characteristics and MEST‐C in Hispanic ethnicity patients.
Shemsu, Elham Sany; Bekele, Bezaye Abebe; Behailu, Etsegenet Gedlu; Kebede, Yabets Tesfaye; Mohammed, Bekri Delil; Kershaw, David
doi: 10.1155/ijne/9489742pmid: N/A
Background: Although chronic kidney disease (CKD) is less prevalent among the pediatric population in comparison to adults, it remains a significant contributor to morbidity and mortality in this age group. As the disease advances, it gives rise to diverse complications, with cardiovascular issues emerging as a primary cause of morbidity and mortality. Remarkably, the intricate association between CKD and left ventricular dysfunction (LVD) has not been extensively investigated in the context of African pediatric populations. This study attempts to close this gap.
Gu, Yue; Zhang, Wenwen; Zhou, Jing; Niu, Xiaoge; Wang, Yanliang; Wang, Limeng; Yan, Lei; Xu, Yang; Shao, Fengmin; Scholze, Alexandra
doi: 10.1155/ijne/5568151pmid: 40236610
Background: Acute kidney injury (AKI) is a common postoperative event. Previous research suggests that intraoperative hypotension (IOH) is associated with postoperative AKI. This connection, however, has not been studied in patients undergoing pancreaticoduodenectomy.
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