Diabetes Obesity and Metabolism

Eissing, Thomas; Goulooze, Sebastiaan Camiel; Berg, Paul; Noort, Martijn; Ruppert, Martijn; Snelder, Nelleke; Garmann, Dirk; Lippert, Joerg; Heinig, Roland; Brinker, Meike; Heerspink, Hiddo J. L.

doi: 10.1111/dom.15489pmid: N/A

doi: 10.1111/dom.15128pmid: N/A

Mikłosz, Agnieszka; Chabowski, Adrian

doi: 10.1111/dom.15375pmid: 38073423

Diabetes mellitus is a highly prevalent disease characterized by hyperglycaemia that damages the vascular system, leading to micro‐ (retinopathy, neuropathy, nephropathy) and macrovascular diseases (cardiovascular disease). There are also secondary complications of diabetes (cardiomyopathy, erectile dysfunction or diabetic foot ulcers). Stem cell‐based therapies have become a promising tool targeting diabetes symptoms and its chronic complications. Among all stem cells, adipose‐derived mesenchymal stem cells (ADMSCs) are of great importance because of their abundance, non‐invasive isolation and no ethical limitations. Characteristics that make ADMSCs good candidates for cell‐based therapy are their wide immunomodulatory properties and paracrine activities through the secretion of an array of growth factors, chemokines, cytokines, angiogenic factors and anti‐apoptotic molecules. Besides, after transplantation, ADMSCs show great ex vivo expansion capacity and differentiation to other cell types, including insulin‐producing cells, cardiomyocytes, chondrocytes, hepatocyte‐like cells, neurons, endothelial cells, photoreceptor‐like cells, or astrocytes. Preclinical studies have shown that ADMSC‐based therapy effectively improved visual acuity, ameliorated polyneuropathy and foot ulceration, arrested the development and progression of diabetic kidney disease, or alleviated the diabetes‐induced cardiomyocyte hypertrophy. However, despite the positive results obtained in animal models, there are still several challenges that need to be overcome before the results of preclinical studies can be translated into clinical applications. To date, there are several clinical trials or ongoing trials using ADMSCs in the treatment of diabetic complications, most of them in the treatment of diabetic foot ulcers. This narrative review summarizes the most recent outcomes on the usage of ADMSCs in the treatment of long‐term complications of diabetes in both animal models and clinical trials.

Song, Yufan; Lu, Sumei; Gao, Fei; Wei, Tianshu; Ma, Wanshan

doi: 10.1111/dom.15390pmid: 38100156

Metabolic diseases have become a major threat to human health worldwide as a result of changing lifestyles. The exploration of the underlying molecular mechanisms of metabolic diseases and the development of improved therapeutic methods have been hindered by the lack of appropriate human experimental models. Organoids are three‐dimensional in vitro models of self‐renewing cells that spontaneously self‐organize into structures similar to the corresponding in vivo tissues, recapitulating the original tissue function. Off‐body organoid technology has been successfully applied to disease modelling, developmental biology, regenerative medicine, and tumour precision medicine. This new generation of biological models has received widespread attention. This article focuses on the construction process and research progress with regard to organoids related to metabolic diseases in recent years, and looks forward to their prospective applications.

Liu, Dan; Li, Nan; Zhou, Yiling; Wang, Miye; Song, Peige; Yuan, Changzheng; Shi, Qingyang; Chen, Hui; Zhou, Kaixin; Wang, Huan; Li, Tao; Pan, Xiong‐Fei; Tian, Haoming; Li, Sheyu

Lee, Yong‐Joon; Lee, Sang‐Hyup; You, Seng Chan; Lee, Yong‐ho; Lee, Seung‐Jun; Hong, Sung‐Jin; Ahn, Chul‐Min; Kim, Byeong‐Keuk; Ko, Young‐Guk; Choi, Donghoon; Hong, Myeong‐Ki; Jang, Yangsoo; Kim, Jung‐Sun

Yu, Congcong; Wang, Yaxin; Zhang, Bing; Xu, Xiang; Zhang, Wen; Ding, Qun; Miao, Yingwen; Hou, Yinjiao; Ma, Xuelin; Wu, Tianyu; Yang, Sijue; Fu, Linqing; Zhang, Zhou; Zhou, Jian; Bi, Yan

Munshi, Medha; Ritzel, Robert; Jude, Edward B; Dex, Terry; Melas‐Melt, Lydie; Rosenstock, Julio

doi: 10.1111/dom.15377pmid: 38082473

Petermann‐Rocha, Fanny; Carrasco‐Marin, Fernanda; Boonpor, Jirapitcha; Parra‐Soto, Solange; Shannon, Oliver; Malcomson, Fiona; Phillips, Nathan; Jain, Mahek; Deo, Salil; Livingstone, Katherine M.; Dingle, Sara E.; Mathers, John C.; Forrest, Ewan; Ho, Frederick K.; Pell, Jill P.; Celis‐Morales, Carlos

Wang, Haixu; He, Siyao; Wang, Jinping; An, Yali; Wang, Xuan; Li, Guangwei; Sun, Ningling; Gong, Qiuhong; ,

doi: 10.1111/dom.15379pmid: 38012837