SHOCK, Vol. 49, No. 4, pp. 355–357, 2018 Commentary Hiroyuki Horiguchi and Philip A. Efron Department of Surgery, University of Florida College of Medicine, Gainesville, Florida As April brings in Spring, this issue of Shock brings another The last review article by Stiel et al. is a comprehensive excellent collection of articles covering the entire gamut of analysis of neutrophil activation during septic shock (3). Our shock, including trauma, sepsis, inflammation, ischemia and knowledge of this leukocyte has evolved significantly over the reperfusion, and other related conditions. This includes three last 2 decades, revealing the importance of this white blood cell review articles, five clinical studies, and six basic science beyond its traditional role as a simple effector cell that kills studies. These manuscripts are not only diverse in the type bacteria. Stiel et al. address the extensive roles of neutrophils in of science being presented (i.e., basic, translational, and clini- innate immunity, in adaptive immunity, and as an immune cal) but derive from some of the best laboratories around the modulator during sepsis. Subsequently, they focus on the roles world. These articles represent how the influence and impact of of neutrophils in immunothrombosis, including the release of the
SHOCK®: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches – Wolters Kluwer Health
Published: Apr 1, 2018
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