Vanishing Bile Duct Syndrome Following Cytomegalovirus Infection in a Child With Hodgkin Lymphoma

Vanishing Bile Duct Syndrome Following Cytomegalovirus Infection in a Child With Hodgkin Lymphoma J Pediatr Hematol Oncol Volume 40, Number 1, January 2018 Letters to the Editor To the Editor: A 7-year-old boy presented with Vanishing Bile Duct intermittent fever and cervical nodes for Hepatic involvement is uncommon 2 years. Diagnosis was classic HL, stage Syndrome Following (5%) at diagnosis in Hodgkin lym- 1,2 IVB (Figs. 1A–C). During evaluation, he phoma (HL). Causes include hepatic Cytomegalovirus developed fever, vomiting, jaundice, and infiltration, biliary obstruction, or viral 2–5 infections. Vanishing bile duct syn- clay-colored stools. Bilirubin was 6 mg/ Infection in a Child dL (direct, 3.4 mg/dL; alanine trans- drome (VBDS) is a rare paraneoplastic 1,5–7 aminase, 212 U/L; aspartate trans- phenomenon associated with HL. With Hodgkin aminase, 219 U/L; alkaline phosphatase, We report a child with HL who devel- 576 U/L; g-glutamyl transferase, 243 oped VBDS following cytomegalovirus Lymphoma U/L). This increased to 12mg/dL over (CMV) infection. FIGURE 1. A, Lymph node biopsy showed complete effacement of the nodal architecture (hematoxylin and eosin, 40). Inset: scattered neoplastic and classic Reed-Sternberg cells (white arrow) in the background of reactive lymphocytes and macrophages (hematoxylin and eosin, 400). B, These atypical cells demonstrated strong membranous and golgi zone positivity for CD30 immunostain (400). Inset: dim http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pediatric Hematology / Oncology Wolters Kluwer Health

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Publisher
Wolters Kluwer Health
Copyright
Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1077-4114
eISSN
1536-3678
D.O.I.
10.1097/MPH.0000000000001048
Publisher site
See Article on Publisher Site

Abstract

J Pediatr Hematol Oncol Volume 40, Number 1, January 2018 Letters to the Editor To the Editor: A 7-year-old boy presented with Vanishing Bile Duct intermittent fever and cervical nodes for Hepatic involvement is uncommon 2 years. Diagnosis was classic HL, stage Syndrome Following (5%) at diagnosis in Hodgkin lym- 1,2 IVB (Figs. 1A–C). During evaluation, he phoma (HL). Causes include hepatic Cytomegalovirus developed fever, vomiting, jaundice, and infiltration, biliary obstruction, or viral 2–5 infections. Vanishing bile duct syn- clay-colored stools. Bilirubin was 6 mg/ Infection in a Child dL (direct, 3.4 mg/dL; alanine trans- drome (VBDS) is a rare paraneoplastic 1,5–7 aminase, 212 U/L; aspartate trans- phenomenon associated with HL. With Hodgkin aminase, 219 U/L; alkaline phosphatase, We report a child with HL who devel- 576 U/L; g-glutamyl transferase, 243 oped VBDS following cytomegalovirus Lymphoma U/L). This increased to 12mg/dL over (CMV) infection. FIGURE 1. A, Lymph node biopsy showed complete effacement of the nodal architecture (hematoxylin and eosin, 40). Inset: scattered neoplastic and classic Reed-Sternberg cells (white arrow) in the background of reactive lymphocytes and macrophages (hematoxylin and eosin, 400). B, These atypical cells demonstrated strong membranous and golgi zone positivity for CD30 immunostain (400). Inset: dim

Journal

Journal of Pediatric Hematology / OncologyWolters Kluwer Health

Published: Jan 1, 2018

References

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