Use of Viable Cryopreserved Placental Membrane as an Adjunct to Facial Keloid Resection

Use of Viable Cryopreserved Placental Membrane as an Adjunct to Facial Keloid Resection Summary: Keloids are the physical manifestation of an exaggerated inflammatory response resulting in excess collagen deposition. The resulting fibroproliferative mass can be distressing for patients due to appearance, pruritus, and/or pain. Despite extensive research into the pathophysiology of keloid formation and the development of numerous treatments, keloids remain a challenge to treat. Even when the initial treatment is successful, a risk of recurrence remains. Basic science research into viable cryopreserved placental membranes and viable cryopreserved umbilical tissue has demonstrated their anti-inflammatory and anti-fibrotic effects, which may decrease keloid recurrence after excision. In this article, we present the first-reported case of viable cryopreserved placental membrane, with living mesenchymal stem cells, to treat a painful preauricular keloid in conjunction with surgical resection. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Plastic & Reconstructive Surgery Global Open Wolters Kluwer Health

Use of Viable Cryopreserved Placental Membrane as an Adjunct to Facial Keloid Resection

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Publisher
Wolters Kluwer
Copyright
Copyright © 2018 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.
eISSN
2169-7574
D.O.I.
10.1097/GOX.0000000000001638
Publisher site
See Article on Publisher Site

Abstract

Summary: Keloids are the physical manifestation of an exaggerated inflammatory response resulting in excess collagen deposition. The resulting fibroproliferative mass can be distressing for patients due to appearance, pruritus, and/or pain. Despite extensive research into the pathophysiology of keloid formation and the development of numerous treatments, keloids remain a challenge to treat. Even when the initial treatment is successful, a risk of recurrence remains. Basic science research into viable cryopreserved placental membranes and viable cryopreserved umbilical tissue has demonstrated their anti-inflammatory and anti-fibrotic effects, which may decrease keloid recurrence after excision. In this article, we present the first-reported case of viable cryopreserved placental membrane, with living mesenchymal stem cells, to treat a painful preauricular keloid in conjunction with surgical resection.

Journal

Plastic & Reconstructive Surgery Global OpenWolters Kluwer Health

Published: Jan 1, 2018

References

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