EDITORIAL Unraveling the Genetic Basis of Recurrent Venous Thromboembolism See Article by de Haan et al Deepak Voora, MD, FAHA Richard C. Becker, MD, FAHA enous thromboembolism (VTE), including deep vein thrombosis and pul- monary embolism, is a worldwide health problem affecting people of all V ages, sexes, cultures, and races. Recent estimates suggest that upward of 10 million people had VTE at an annual cost from hospitalization, treatment, and 1,2 days lost from work of at least $60 billion. It is prevalent in low-, middle-, and high-income countries with annual incidence rates ranging from 0.75 to 2.69 per 1000 individuals. In addition, VTE is among the leading causes of disability-adjust- 3 4 ed life years lost. In the Global Burden of Disease Project, incidence rates for VTE were 115 and 269 per 100 000 people among men and women, respectively, and mortality rates ranged from 9.4 to 32.3. Despite the burden of VTE, global public awareness was ≈50% lower compared with myocardial infarction or stroke. VTE is often associated with recurrence after convalescence from the initial event. An unprovoked initial VTE is a particularly strong risk factor for recurrence, suggesting that ≥1 underlying genetic factors may play an
Circulation: Cardiovascular Genetics – Wolters Kluwer Health
Published: Feb 1, 2018
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