Unraveling the Genetic Basis of Recurrent Venous Thromboembolism

Unraveling the Genetic Basis of Recurrent Venous Thromboembolism EDITORIAL Unraveling the Genetic Basis of Recurrent Venous Thromboembolism See Article by de Haan et al Deepak Voora, MD, FAHA Richard C. Becker, MD, FAHA enous thromboembolism (VTE), including deep vein thrombosis and pul- monary embolism, is a worldwide health problem affecting people of all V ages, sexes, cultures, and races. Recent estimates suggest that upward of 10 million people had VTE at an annual cost from hospitalization, treatment, and 1,2 days lost from work of at least $60 billion. It is prevalent in low-, middle-, and high-income countries with annual incidence rates ranging from 0.75 to 2.69 per 1000 individuals. In addition, VTE is among the leading causes of disability-adjust- 3 4 ed life years lost. In the Global Burden of Disease Project, incidence rates for VTE were 115 and 269 per 100 000 people among men and women, respectively, and mortality rates ranged from 9.4 to 32.3. Despite the burden of VTE, global public awareness was ≈50% lower compared with myocardial infarction or stroke. VTE is often associated with recurrence after convalescence from the initial event. An unprovoked initial VTE is a particularly strong risk factor for recurrence, suggesting that ≥1 underlying genetic factors may play an http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation: Cardiovascular Genetics Wolters Kluwer Health

Unraveling the Genetic Basis of Recurrent Venous Thromboembolism

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Publisher
Wolters Kluwer Health
Copyright
© 2018 American Heart Association, Inc.
ISSN
1942-325X
eISSN
1942-3268
D.O.I.
10.1161/CIRCGEN.117.002047
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL Unraveling the Genetic Basis of Recurrent Venous Thromboembolism See Article by de Haan et al Deepak Voora, MD, FAHA Richard C. Becker, MD, FAHA enous thromboembolism (VTE), including deep vein thrombosis and pul- monary embolism, is a worldwide health problem affecting people of all V ages, sexes, cultures, and races. Recent estimates suggest that upward of 10 million people had VTE at an annual cost from hospitalization, treatment, and 1,2 days lost from work of at least $60 billion. It is prevalent in low-, middle-, and high-income countries with annual incidence rates ranging from 0.75 to 2.69 per 1000 individuals. In addition, VTE is among the leading causes of disability-adjust- 3 4 ed life years lost. In the Global Burden of Disease Project, incidence rates for VTE were 115 and 269 per 100 000 people among men and women, respectively, and mortality rates ranged from 9.4 to 32.3. Despite the burden of VTE, global public awareness was ≈50% lower compared with myocardial infarction or stroke. VTE is often associated with recurrence after convalescence from the initial event. An unprovoked initial VTE is a particularly strong risk factor for recurrence, suggesting that ≥1 underlying genetic factors may play an

Journal

Circulation: Cardiovascular GeneticsWolters Kluwer Health

Published: Feb 1, 2018

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