Therapeutic Lowering of Lipoprotein(a)

Therapeutic Lowering of Lipoprotein(a) EDITORIAL A Role for Pharmacogenetics? See Article by Parish, Hopewell, and Hill et al Michael B. Boffa, PhD Marlys L. Koschinsky, PhD e are on the cusp of having elevated plasma concentrations of lipoprotein(a) as a therapeutic target for cardiovascular disease (CVD). WRecent large population studies and meta-analyses, genome-wide asso- ciation studies, and Mendelian randomization studies have identified elevated lipoprotein(a) as an independent, causal risk factor for coronary heart disease and other atherothrombotic disorders. Elevated lipoprotein(a) is also emerging as a key risk factor for calcific aortic valve disease. Several therapeutic modalities capable of lowering lipoprotein(a) are in the marketplace or are in clinical trials. Yet, sev- eral obstacles remain. Most importantly, it has not been directly demonstrated that lowering lipoprotein(a) produces a clinical benefit, and to what extent lipoprotein(a) must be lowered to derive such a benefit. Beyond this, there remain fundamental unanswered questions on how lipoprotein(a) concentrations are established and the mechanisms underlying the lipoprotein(a)-lowering effects of current therapies. The article by Parish et al in this issue, describing a substudy of the Heart Protec- tion Study 2–Treatment of HDL to Reduce the Incidence of Vascular Events (HPS2- THRIVE) randomized controlled trial of niacin/laropiprant, sheds interesting new http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation: Cardiovascular Genetics Wolters Kluwer Health

Therapeutic Lowering of Lipoprotein(a)

Loading next page...
 
/lp/wolters_kluwer/therapeutic-lowering-of-lipoprotein-a-qPMUadNiuY
Publisher
Wolters Kluwer
Copyright
© 2018 American Heart Association, Inc.
ISSN
1942-325X
eISSN
1942-3268
D.O.I.
10.1161/CIRCGEN.118.002052
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL A Role for Pharmacogenetics? See Article by Parish, Hopewell, and Hill et al Michael B. Boffa, PhD Marlys L. Koschinsky, PhD e are on the cusp of having elevated plasma concentrations of lipoprotein(a) as a therapeutic target for cardiovascular disease (CVD). WRecent large population studies and meta-analyses, genome-wide asso- ciation studies, and Mendelian randomization studies have identified elevated lipoprotein(a) as an independent, causal risk factor for coronary heart disease and other atherothrombotic disorders. Elevated lipoprotein(a) is also emerging as a key risk factor for calcific aortic valve disease. Several therapeutic modalities capable of lowering lipoprotein(a) are in the marketplace or are in clinical trials. Yet, sev- eral obstacles remain. Most importantly, it has not been directly demonstrated that lowering lipoprotein(a) produces a clinical benefit, and to what extent lipoprotein(a) must be lowered to derive such a benefit. Beyond this, there remain fundamental unanswered questions on how lipoprotein(a) concentrations are established and the mechanisms underlying the lipoprotein(a)-lowering effects of current therapies. The article by Parish et al in this issue, describing a substudy of the Heart Protec- tion Study 2–Treatment of HDL to Reduce the Incidence of Vascular Events (HPS2- THRIVE) randomized controlled trial of niacin/laropiprant, sheds interesting new

Journal

Circulation: Cardiovascular GeneticsWolters Kluwer Health

Published: Feb 1, 2018

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from
Google Scholar,
PubMed
Create lists to
organize your research
Export lists, citations
Read DeepDyve articles
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off