AbstractObjective:Menopause is associated with adverse changes in hematological parameters. Although the antioxidative and anti-inflammatory properties of vitamin E have been previously demonstrated, the effects of vitamin E on hematopoietic parameters are not well-documented. This study investigated the effects of supplemental vitamin E on hematological parameters in a rat model of ovarian hormone deficiency.Methods:Twelve-month-old female Sprague-Dawley rats were either sham-operated (Sham) or ovariectomized (Ovx). Animals were randomly divided among five treatment groups (n = 12/group) as follows: Sham; Ovx; Ovx + 300, Ovx + 525, or Ovx + 750 mg/kg diet of vitamin E for 100 days.Results:Compared with Sham, ovariectomy increased leukocyte subpopulation counts including lymphocytes (2.01 × 103/mm3; 95% confidence interval [CI] 0.11, 4.03; P = 0.03), monocytes (0.35 × 103/mm3; 95% CI 0.60, 0.11; P = 0.01), neutrophils (0.72 × 103/mm3; 95% CI 0.26, 1.19; P = 0.01), eosinophils (0.07 × 103/mm3; 95% CI 0.12, 0.30; P = 0.00), and basophils (0.13 × 103/mm3; 95% CI 0.04, 0.21; P = 0.02). Medium dose (MD) (−0.26 × 103/mm3; 95% CI −0.47, −0.05; P = 0.007) and high dose (HD) (−0.22 × 103/mm3; 95% CI −0.43, −0.01; P = 0.037) supplemental vitamin E attenuated Ovx-induced increases in monocyte counts. Low dose (LD) (−0.55 × 103/mm3; 95% CI −0.95, −0.15; P = 0.003), MD (−0.61 × 103/mm3; P = 0.001), and HD (−0.54 × 103/mm3; 95% CI −0.95, −0.14; P = 0.004) supplemental vitamin E attenuated Ovx-induced increases in neutrophil counts. LD (−0.05 × 103/mm3; 95% CI −0.08, −0.11; P = 0.006), MD (−0.05 × 103/mm3; 95% CI −0.08, −0.11; P = 0.005), and HD (−0.05 × 103/mm3; 95% CI −0.09, −0.01; P = 0.004) supplemental vitamin E also attenuated the Ovx-induced increase in eosinophil counts. Only LD (−0.09 × 103/mm3; 95% CI −0.17, −0.02; P = 0.009) supplemental vitamin E attenuated the Ovx-induced increase in basophil counts. The remaining hematological parameters assessed were not significantly affected by ovariectomy or supplemental vitamin E.Conclusion:These findings suggest that vitamin E in the form of α-tocopherol acetate may provide protection against ovarian hormone deficiency-associated adverse changes in hematological parameters.
Menopause – Wolters Kluwer Health
Published: Mar 1, 2018
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