EDITORIAL URRENT PINION Reinhard Dummer Ten years ago, surgery was the only reliable treat- immunotherapies, or we can use other immune ment option in most skin cancers. Medical therapy modulators such as anti-tumor necrosis factor including chemotherapy was standard of care with- strategies earlier. out any benefit concerning overall survival. Moreover, we can search for additional combi- Many patients with advanced melanoma nation agents that are specifically selected for the individual patient, such as concept precision immu- received monochemotherapy with dacarbazine for metastatic disease. Others were treated with high- notherapy. With this, there is a good chance that dose interleukin 2. This treatment causes substantial the overall outcome of immunotherapy will be side-effects and many medical complications. improved. A new molecule in development is epa- In the adjuvant situation, high-dose interferon a cadostat, an IDO1 inhibitor that has demonstrated was used. Interferon a has an impact on the out- promising progression-free survival, as well as come, however, again this therapy was quiet toxic. a good response rate and favorable safety profile Many patients suffered for months from flu-like compared with current monotherapies. symptoms and some also from depression. On the Targeted therapies achieve response rates of basis of a
Current Opinion in Oncology – Wolters Kluwer Health
Published: Mar 1, 2018
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