INVITED COMMENTARIES to support these concerns is either inductive or based on experi- Splenda in the Milk: Hitting the mental models and emerging human data. Concerns about individ- Sweet Spot ual NNS may not be generalizable to others and in turn there are likely to be different responses in individuals. Richard Thomas Lee Couper and Jenny Couper ALTERED TASTE PREFERENCES Taste preferences are established early in life. Any pediatri- cian who has tried to introduce an elemental formula after 6 months Invited Commentary on: ‘‘Pharmacokinetics of Sucralose of age knows how difficult this compared to early exposure. Taste and Acesulfame-Potassium in Breast Milk Following may be determined either by peripheral stimulation of the G- Ingestion of Diet Soda’’ by Rother et al on page 466. protein–coupled sweet receptor (3), by a possible opioid mediated pathway, or by direct hypothalamic stimulation. Support for pe- ripheral stimulation comes from the studies showing reduction of reast milk is a nutritive soup unique to each individual mother pain in infants by high concentration sucrose to nociceptive stimuli and her infant. It varies from day to day, and its composition is B such as heel prick and vaccination. Reduction of discomfort may influenced by
Journal of Pediatric Gastroenterology & Nutrition – Wolters Kluwer Health
Published: Mar 1, 2018
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