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E. Ball, J. Wilson, V. Phelps, S. Neudorf (2000)
Autologous bone marrow transplantation for acute myeloid leukemia in remission or first relapse using monoclonal antibody-purged marrow: results of phase II studies with long-term follow-upBone Marrow Transplantation, 25
D. Breems, M. Boogaerts, A. Dekker, W. Putten, P. Sonneveld, P. Huijgens, J. Lelie, E. Vellenga, A. Gratwohl, G. Verhoef, L. Verdonck, B. Löwenberg (2005)
Autologous bone marrow transplantation as consolidation therapy in the treatment of adult patients under 60 years with acute myeloid leukaemia in first complete remission: a prospective randomized Dutch–Belgian Haemato‐Oncology Co‐operative Group (HOVON) and Swiss Group for Clinical Cancer ResearchBritish Journal of Haematology, 128
J. Harousseau, J. Cahn, B. Pignon, F. Witz, N. Milpied, M. Delain, B. Lioure, T. Lamy, B. Desablens, F. Guilhot, D. Caillot, J. Abgrall, S. François, J. Briére, D. Guyotat, P. Casassus, B. Audhuy, Z. Tellier, P. Hurteloup, P. Hervé (1997)
Comparison of autologous bone marrow transplantation and intensive chemotherapy as postremission therapy in adult acute myeloid leukemia. The Groupe Ouest Est Leucémies Aiguës Myéloblastiques (GOELAM).Blood, 90 8
N. Gorin, M. Labopin, S. Piemontese, W. Arcese, S. Santarone, He Huang, G. Meloni, F. Ferrara, D. Beelen, M. Sanz, A. Bacigalupo, F. Ciceri, Audrey Mailhol, A. Nagler, M. Mohty (2015)
T-cell-replete haploidentical transplantation versus autologous stem cell transplantation in adult acute leukemia: a matched pair analysisHaematologica, 100
M. Luskin, R. Stone (2017)
Can Minimal Residual Disease Determination in Acute Myeloid Leukemia Be Used in Clinical Practice?Journal of oncology practice, 13 8
Jianfeng Yao, Gui-xin Zhang, C. Liang, Gang Li, Xin Chen, Qiao-ling Ma, W. Zhai, Donglin Yang, Yi He, E. Jiang, S. Feng, Mingzhe Han (2017)
Combination of cytogenetic classification and MRD status correlates with outcome of autologous versus allogeneic stem cell transplantation in adults with primary acute myeloid leukemia in first remission.Leukemia research, 55
J. Versluis, F. Hout, R. Devillier, W. Putten, M. Manz, M. Vekemans, M. Legdeur, Jakob Passweg, J. Maertens, J. Kuball, B. Biemond, P. Valk, B. Reijden, G. Meloni, H. Schouten, E. Vellenga, T. Pabst, R. Willemze, B. Lowenberg, G. Ossenkoppele, F. Baron, G. Huls, J. Cornelissen (2016)
Comparative value of post-remission treatment in cytogenetically normal AML subclassified by NPM1 and FLT3-ITD allelic ratioLeukemia, 31
N. Gorin (2016)
Autologous stem cell transplantation versus alternative allogeneic donor transplants in adult acute leukemias.Seminars in Hematology, 53
B. Smith, Richard Jones, Shing-Mou Lee, S. Piantadosi, M. Vala, D. Fuller, S. Gore, S. Noga, P. O'Donnell, H. Braine, G. Vogelsang, E. Fuchs, I. Flinn, R. Brodsky, R. Ambinder, Carole Miller (2002)
Autologous bone marrow transplantation with 4‐hydroperoxycyclophosphamide purging for acute myeloid leukaemia beyond first remission: a 10‐year experienceBritish Journal of Haematology, 117
(2016)
Long-term follow-up of patients with acute myeloid leukemia surviving and free of disease recurrence for at least 2 years after autologous stem cell transplantation: a report from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, 122
Motonori Mizutani, A. Takami, M. Hara, Shohei Mizuno, M. Yanada, T. Chou, H. Uchiyama, K. Ohashi, T. Miyamoto, Y. Ozawa, O. Imataki, N. Kobayashi, N. Uchida, H. Kanamori, T. Kamimura, T. Eto, M. Onizuka, J. Tanaka, Y. Atsuta, S. Yano (2017)
Comparison of Autologous and Unrelated Transplants for Cytogenetically Normal Acute Myelogenous Leukemia.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 23 9
(2016)
Comparable outcomes between autologous and allogeneic transplant for adult acute myeloid leukemia in first CR, 51
(2015)
aged 40 – 60 years
C. Messina, A. Candoni, M. Carrabba, C. Tresoldi, E. Sala, M. Tassara, A. Crippa, J. Peccatori, A. Assanelli, S. Gattillo, L. Bellio, R. Fanin, F. Ciceri, M. Bernardi (2014)
Wilms' tumor gene 1 transcript levels in leukapheresis of peripheral blood hematopoietic cells predict relapse risk in patients autografted for acute myeloid leukemia.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 20 10
(2017)
Autologous stem cell transplantation for adult acute myelocytic leukemia in first remission-better outcomes after busulfan and melphalan compared with busulfan and cyclophosphamide: A retrospective study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT), 123
(2015)
Comparative therapeutic value of postremission approaches in patients with acute myeloid leukemia aged 40–60 years, 29
P. Cassileth, D. Harrington, F. Appelbaum, H. Lazarus, J. Rowe, E. Paietta, C. Willman, D. Hurd, J. Bennett, K. Blume, D. Head, P. Wiernik (1998)
Chemotherapy compared with autologous or allogeneic bone marrow transplantation in the management of acute myeloid leukemia in first remission.The New England journal of medicine, 339 23
(1998)
Randomised comparison of addition of autologous bone-marrow transplantation to intensive chemotherapy for acute myeloid leukaemia in first remission: results of MRC AML 10 trial. UK Medical Research Council Adult and Children's Leukaemia Working Parties, 351
R. Schlenk, E. Taskesen, Y. Norden, J. Krauter, A. Ganser, L. Bullinger, V. Gaidzik, P. Paschka, A. Corbacioglu, G. Göhring, A. Kündgen, G. Held, K. Götze, E. Vellenga, J. Kuball, U. Schanz, J. Passweg, T. Pabst, J. Maertens, G. Ossenkoppele, R. Delwel, H. Döhner, J. Cornelissen, K. Döhner, B. Löwenberg (2013)
The value of allogeneic and autologous hematopoietic stem cell transplantation in prognostically favorable acute myeloid leukemia with double mutant CEBPA.Blood, 122 9
(2016)
Comparable outcomes between auto- logous and allogeneic transplant for adult acute myeloid leukemia in first CR. Bone Marrow Transplant 2016; 51:645–653
Matthew Mulè, G. Mannis, B. Wood, J. Radich, Jimmy Hwang, N. Ramos, C. Andreadis, L. Damon, A. Logan, T. Martin, C. Hourigan (2016)
Multigene Measurable Residual Disease Assessment Improves Acute Myeloid Leukemia Relapse Risk Stratification in Autologous Hematopoietic Cell Transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 22 11
N. Gorin, M. Labopin, D. Blaise, J. Reiffers, G. Meloni, M. Michallet, T. Witte, M. Attal, B. Rio, F. Witz, L. Fouillard, R. Willemze, V. Rocha (2009)
Higher incidence of relapse with peripheral blood rather than marrow as a source of stem cells in adults with acute myelocytic leukemia autografted during the first remission.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 27 24
E. Vellenga, W. Putten, G. Ossenkoppele, L. Verdonck, M. Theobald, J. Cornelissen, P. Huijgens, J. Maertens, A. Gratwohl, R. Schaafsma, U. Schanz, C. Graux, H. Schouten, A. Ferrant, M. Bargetzi, M. Fey, B. Löwenberg (2011)
Autologous peripheral blood stem cell transplantation for acute myeloid leukemia.Blood, 118 23
F. Saraceni, M. Labopin, N. Gorin, D. Blaise, R. Tabrizi, L. Volin, J. Cornelissen, J. Cahn, P. Chevallier, C. Craddock, Depei Wu, A. Huynh, W. Arcese, M. Mohty, A. Nagler (2016)
Matched and mismatched unrelated donor compared to autologous stem cell transplantation for acute myeloid leukemia in first complete remission: a retrospective, propensity score-weighted analysis from the ALWP of the EBMTJournal of Hematology & Oncology, 9
Comparative therapeutic value of postremission approaches in patients with acute myeloid
P. Chevallier, M. Labopin, G. Socié, M. Rubio, D. Blaise, S. Vigouroux, A. Huynh, M. Michallet, J. Bay, S. Maury, I. Yakoub-Agha, N. Fegueux, E. Deconinck, N. Contentin, N. Maillard, C. Bulabois, S. François, R. Oumedaly, N. Raus, M. Mohty (2015)
Comparison of umbilical cord blood allogeneic stem cell transplantation vs. auto‐SCT for adult acute myeloid leukemia patients in second complete remission at transplant: a retrospective study on behalf of the SFGM‐TCEuropean Journal of Haematology, 94
F. Saraceni, B. Bruno, R. Lemoli, G. Meloni, W. Arcese, M. Falda, F. Ciceri, E. Alessandrino, G. Specchia, R. Scimé, R. Raimondi, A. Bacigalupo, A. Bosi, F. Onida, A. Rambaldi, F. Bonifazi, A. Olivieri (2017)
Autologous stem cell transplantation is still a valid option in good- and intermediate-risk AML: a GITMO survey on 809 patients autografted in first complete remissionBone Marrow Transplantation, 52
Purpose of reviewAutologous hematopoietic cell transplantation (auto-HCT) has been evaluated as a consolidation treatment for acute myeloid leukemia (AML) in the 1980s and 1990s. These prospective studies from large trials compared auto-HCT with chemotherapy. A comparison was made also with allogeneic hematopoietic cell transplantation (allo-HCT). These studies reported a lower relapse rate with auto-HCT compared with chemotherapy, but without impact on the overall survival. A high transplant-related mortality in that era confounded the relevance of these data.Recent findingsSeveral prospective studies and a plethora of retrospective registry data have confirmed the potent antileukemic therapy of auto-HCT compared with chemotherapy and, in some instances, have even challenged the presumed superiority of allo-HCT as the definitive therapy for certain patients with AML.SummaryThe aggregate of recent data, prospective and retrospective, strongly suggests an important role for auto-HCT, at least as the most potent nonimmunologic antileukemia therapy. The transplant-related mortality in 2017 is close to that expected from standard consolidation therapy leading to the conclusion that the role of auto-HCT needs to be rigorously revisited, preferably in prospective studies, to establish its precise role in the current era.
Current Opinion in Hematology – Wolters Kluwer Health
Published: Mar 1, 2018
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