Revealing Pathways of Cardiac Regeneration

Revealing Pathways of Cardiac Regeneration EDITORIAL Revealing Pathways of Cardiac Regeneration See Article by Adamowicz, Morgan, and Haubner et al Vinícius Bassaneze, MSc, PhD Richard T. Lee, MD ajor cardiac injuries like a large myocardial infarction lead to systolic heart failure because of loss of cardiomyocytes. Unlike during embryonic Mdevelopment, adult mammalian cardiomyocytes have limited ability to proliferate and replenish the adult mammalian heart. Although there was once excitement over possible adult cardiac stem cells residing in the mammalian myo- cardium, it now seems that there are insufficient cardiac progenitor cells in the heart to generate any meaningful regeneration. More recently, it was discovered that the heart’s regenerative ability is preserved in the first hours after birth in 3 4 mice and rats. Indeed, cardiac regeneration may be recapitulated in vitro using immature human heart organoids, indicating an innate capacity of some cardio- myocytes for regeneration. These and other recent discoveries have advanced our understanding of how the mammalian heart can regenerate under certain circum- stances, potentially setting the stage for us to appreciate why adult human hearts fail to regenerate. Modern genomic technology can provide a broad molecular characterization of specific cell and tissue states. In this issue of Circulation: Genomic and Precision Medicine, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation: Cardiovascular Genetics Wolters Kluwer Health

Revealing Pathways of Cardiac Regeneration

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Publisher
Wolters Kluwer
Copyright
© 2018 American Heart Association, Inc.
ISSN
1942-325X
eISSN
1942-3268
D.O.I.
10.1161/CIRCGEN.117.002053
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL Revealing Pathways of Cardiac Regeneration See Article by Adamowicz, Morgan, and Haubner et al Vinícius Bassaneze, MSc, PhD Richard T. Lee, MD ajor cardiac injuries like a large myocardial infarction lead to systolic heart failure because of loss of cardiomyocytes. Unlike during embryonic Mdevelopment, adult mammalian cardiomyocytes have limited ability to proliferate and replenish the adult mammalian heart. Although there was once excitement over possible adult cardiac stem cells residing in the mammalian myo- cardium, it now seems that there are insufficient cardiac progenitor cells in the heart to generate any meaningful regeneration. More recently, it was discovered that the heart’s regenerative ability is preserved in the first hours after birth in 3 4 mice and rats. Indeed, cardiac regeneration may be recapitulated in vitro using immature human heart organoids, indicating an innate capacity of some cardio- myocytes for regeneration. These and other recent discoveries have advanced our understanding of how the mammalian heart can regenerate under certain circum- stances, potentially setting the stage for us to appreciate why adult human hearts fail to regenerate. Modern genomic technology can provide a broad molecular characterization of specific cell and tissue states. In this issue of Circulation: Genomic and Precision Medicine,

Journal

Circulation: Cardiovascular GeneticsWolters Kluwer Health

Published: Feb 1, 2018

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